Characterization of the hypnotic properties of oleamide
Characterization of the hypnotic properties of oleamide
复制标题
DOI：
10.1097/00001756-199904060-00010
复制
发表时间：
1999-04-06
期刊：
影响因子：
1.7
通讯作者：
Mendelson, WB
中科院分区：
文献类型：
--
作者：
Basile, AS;Hanus, L;Mendelson, WB
虽然初步研究将油酰胺与睡眠调节联系起来，但我们现在使用许多技术来描述油酰胺在睡眠中的作用。大鼠外周给予油酰胺可剂量依赖性地抑制旷场运动活动，减少运动距离的ED 50为17+/-1.5 mg/kg。此外，内源性油酰胺浓度增加3- 4倍，在大鼠的脑脊液中睡眠剥夺6小时或更长时间。油酰胺还将睡眠潜伏期降低至对照值的44-64%，而不改变其他睡眠参数。与许多假定的内源性睡眠诱导剂不同，油酰胺有效地诱导睡眠的行为和脑电图表现。此外，其内源性浓度和时间关联与先前的报告一致，其增强多巴胺能和GABA能神经传递，这可能涉及睡眠诱导。NeuroReport 10：947-951（C）1999 Lippincott威廉姆斯和威尔金斯。
WHILE preliminary studies associated oleamide with sleep regulation, we now characterize the involvement of oleamide in sleep using a number of techniques. Peripheral administration of oleamide to rats dose dependently suppressed motor activity in the open field, with an ED50 of 17+/-1.5 mg/kg for the decrease in distance traveled. Moreover, endogenous oleamide concentrations increased 3- to 4-fold in the cerebrospinal fluid of rats sleep-deprived for 6 h or longer. Oleamide also decreased sleep latency to 44-64% of control values without altering other sleep parameters. Unlike many putative endogenous sleep-inducing agents, oleamide potently induces behavioral and electroencephalographic manifestations of sleep. Moreover, its endogenous concentrations and temporal associations are consistent with previous reports of its enhancement of serotonergic and GABAergic neurotransmission, which may be involved in sleep induction. NeuroReport 10:947-951 (C) 1999 Lippincott Williams & Wilkins.