Is mPTP the gatekeeper for necrosis, apoptosis, or both?
Is mPTP the gatekeeper for necrosis, apoptosis, or both?
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DOI：
10.1016/j.bbamcr.2010.09.013
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发表时间：
2011-04
期刊：
影响因子：
--
通讯作者：
Dejean LM
中科院分区：
文献类型：
--
作者：
Kinnally KW;Peixoto PM;Ryu SY;Dejean LM
线粒体膜的透化是细胞凋亡和坏死的关键步骤。这种现象允许释放线粒体死亡因子，从而触发或促进不同的信号级联反应，最终导致细胞的执行。线粒体通透性转换孔（mPTP）长期以来被认为是细胞死亡过程中线粒体的主要调节因子之一。 mPTP 打开可导致基质肿胀、随后外膜破裂以及膜间隙蛋白非特异性释放到细胞质中。虽然 mPTP 据称与早期细胞凋亡有关，但最近的观察表明，mPTP 介导的线粒体通透化通常与晚期细胞凋亡和坏死事件的关系更为密切。细胞死亡过程中线粒体膜透化的机制已被假设，涉及三种不同的线粒体通道。这些包括内膜中的 mPTP，以及外膜中的线粒体凋亡诱导通道 (MAC) 和电压依赖性阴离子选择性通道 (VDAC)。探讨了 mPTP 结构和功能的新进展，以及 mPTP、MAC 和 VDAC 在细胞死亡过程中线粒体膜透化中的作用。
Permeabilization of the mitochondrial membranes is a crucial step in apoptosis and necrosis. This phenomenon allows the release of mitochondrial death factors which trigger or facilitate different signaling cascades ultimately causing the execution of the cell. The mitochondrial permeability transition pore (mPTP) has long been known as one of the main regulators of mitochondria during cell death. mPTP opening can lead to matrix swelling, subsequent rupture of the outer membrane and a nonspecific release of intermembrane space proteins into the cytosol. While mPTP was purportedly associated with early apoptosis, recent observations suggest that mitochondrial permeabilization mediated by mPTP is generally more closely linked to events of late apoptosis and necrosis. Mechanisms of mitochondrial membrane permeabilization during cell death, involving three different mitochondrial channels, have been postulated. These include the mPTP in the inner membrane, and the mitochondrial apoptosis-induced channel (MAC) and voltage dependent anion-selective channel (VDAC) in the outer membrane. New developments on mPTP structure and function, and the involvement of mPTP, MAC, and VDAC in permeabilization of mitochondrial membranes during cell death are explored.
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影响因子：
64.5
作者：
Cárdenas C;Miller RA;Smith I;Bui T;Molgó J;Müller M;Vais H;Cheung KH;Yang J;Parker I;Thompson CB;Birnbaum MJ;Hallows KR;Foskett JK
通讯作者：
Foskett JK
DOI：
10.1073/pnas.0708959104
发表时间：
2007-11-13
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
3.4
作者：
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通讯作者：
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影响因子：
64.8
作者：
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通讯作者：
Molkentin, JD
影响因子：
4.8
作者：
Basso, Emy;Petronilli, Valeria;Bernardi, Paolo
通讯作者：
Bernardi, Paolo