Regional heterogeneity in the developing palate: morphological and molecular evidence for normal and abnormal palatogenesis
Regional heterogeneity in the developing palate: morphological and molecular evidence for normal and abnormal palatogenesis
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DOI：
10.1111/j.1741-4520.2006.00103.x
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发表时间：
2006-06-01
影响因子：
1.3
通讯作者：
Shiota, Kohei
中科院分区：
文献类型：
--
作者：
Okano, Junko;Suzuki, Shigehiko;Shiota, Kohei
哺乳动物次生腭的发育涉及腭架的生长、升高、内侧延伸和中线融合。近年来对腭发生的形态学和分子生物学研究表明，发育中的腭不是一个同质的器官，而是各个部分在器官发生过程中的不同表现。特别是，一些参与腭发育的关键分子已被证明在腭组织中表现出异质性表达模式。因此，在分析正常和异常形态发生的机制时，有必要认识到发育中的腭沿着背腹轴和前后轴的区域异质性。基于最近的研究，我们讨论了胎儿腭的区域异质性问题，并提出了一个原则，将胎儿腭分为几个区域，从形态学和分子的观点。
Development of the mammalian secondary palate involves the growth, elevation, medial elongation and midline fusion of palatal shelves. Recent morphological and molecular studies on palatogenesis suggest that the developing palate is not a homogeneous organ but each part may behave differently during organogenesis. Especially, some key molecules involved in palate development have been shown to exhibit heterogeneous patterns of expression in the palatal tissue. Therefore it seems necessary to recognize the regional heterogeneity of the developing palate along the dorsoventral and anteroposterior axes when analyzing the mechanisms of normal and abnormal morphogenesis. Based on recent studies, we discuss the issue of the regional heterogeneity in the fetal palate and propose a principle that divides the fetal palate into several regions from the morphological and molecular standpoint.