HLA class I and II alleles in susceptibility to ankylosing spondylitis.
HLA class I and II alleles in susceptibility to ankylosing spondylitis.
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DOI：
10.1136/annrheumdis-2018-213779
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发表时间：
2019-01
影响因子：
27.4
通讯作者：
Brown MA
中科院分区：
文献类型：
--
作者：
Reveille JD;Zhou X;Lee M;Weisman MH;Yi L;Gensler LS;Zou H;Ward MM;Ishimori ML;Learch TJ;He D;Rahbar MH;Wang J;Brown MA
目的：研究强直性脊柱炎(AS)与人类白细胞抗原I、II类等位基因的相关性。中国对1948例无血缘关系的白人和67例非裔美国人AS患者、北美强直性脊柱炎协会和澳大利亚-英美脊柱炎协会、990名白人和245名非洲裔美国人AS患者和346名上海和甘肃对照人群进行了HLAA-A、-B、-C、-DRB1、-DQB1和-DPB1等位基因分型。除病例对照分析外，分别对HLA-B*27阴性AS患者进行分析，并进行Logistic回归分析和“相对易感效应”(RPE)分析，以控制HLA-B*27对疾病易感性的主要影响。虽然在白种人中发现了许多与人类白细胞相关的等位基因，但在人类白细胞抗原B*27阴性的AS患者中，与人类白细胞抗原A*29、B*38、B*49、B*52、DRB1*11和DPB1*03：01呈正相关，与人类白细胞抗原-B*07、-B*57、-DRB1*15：01、-DQB1*02：01和-DQB1*06：02呈负相关。RPE分析还发现了与人类白细胞抗原-B*14和B*40(B60)的关联，排除了人类白细胞抗原-B*27等位基因。在汉族人和非裔美国人AS患者中，HLAB*40：01频率升高，HLAB*07频率降低。急性前葡萄膜炎患者外周血中HL A-B*08降低。这些数据分析了迄今为止在三个民族中接受检查的最大数量的AS患者，证实了除HLA-B*27以外的其他HLAI和II类等位基因在AS易感性中起作用。
To examine associations of HLA class I and class II alleles with ankylosing spondylitis (AS) in three cohorts of patients of European, Asian and African ancestry. HLA-A, -B, -C, -DRB1, -DQB1 and -DPB1 alleles were genotyped in 1948 unrelated white and 67 African-American AS patients from the Prospective Study of Outcomes in Ankylosing Spondylitis (PSOAS) cohort, the North American Spondylitis Consortium (NASC) and Australo-Anglo-American Spondyloarthritis Consortium (TASC), 990 white and 245 African American Controls and HLA-B alleles in 442 Han Chinese AS patients and 346 controls from Shanghai and Gansu, China. In addition to the case:control analyses, HLA-B*27 negative AS patients were analyzed separately, and logistic regression and “relative predispositional effects” (RPE) analyses were carried out to control for the major effect of HLA-B*27on disease susceptibility. Although numerous associations were seen between HLA alleles and AS in whites, among HLA-B*27 negative AS patients, positive associations were seen with HLA-A*29, B*38, B*49, B*52, DRB1*11 and DPB1*03:01 and negative associations with HLA-B*07, -B*57, -DRB1*15:01, -DQB1*02:01 and -DQB1*06:02. Additional associations with HLA-B*14 and B*40 (B60) were observed via RPE analysis, which excludes the HLA-B*27 alleles. The increased frequency of HLA-B*40:01 and decreased frequency of HLA-B*07 was also seen in Han Chinese and African-Americans with AS. HLA-B*08 was decreased in whites with acute anterior uveitis. These data, analyzing the largest number of AS patients examined to date in three ethnic groups, confirm that other HLA class I and II alleles other than HLA-B*27 to be operative in AS predisposition.
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影响因子：
2.9
作者：
Londono, John;Maria Santos, Ana;Medina, Juan F.
通讯作者：
Medina, Juan F.
影响因子：
30.8
作者：
Ellinghaus D;Jostins L;Spain SL;Cortes A;Bethune J;Han B;Park YR;Raychaudhuri S;Pouget JG;Hübenthal M;Folseraas T;Wang Y;Esko T;Metspalu A;Westra HJ;Franke L;Pers TH;Weersma RK;Collij V;D'Amato M;Halfvarson J;Jensen AB;Lieb W;Degenhardt F;Forstner AJ;Hofmann A;International IBD Genetics Consortium (IIBDGC);International Genetics of Ankylosing Spondylitis Consortium (IGAS);International PSC Study Group (IPSCSG);Genetic Analysis of Psoriasis Consortium (GAPC);Psoriasis Association Genetics Extension (PAGE);Schreiber S;Mrowietz U;Juran BD;Lazaridis KN;Brunak S;Dale AM;Trembath RC;Weidinger S;Weichenthal M;Ellinghaus E;Elder JT;Barker JN;Andreassen OA;McGovern DP;Karlsen TH;Barrett JC;Parkes M;Brown MA;Franke A
通讯作者：
Franke A
影响因子：
29.4
作者：
Orchard, TR;Thiyagaraja, S;Jewell, DP
通讯作者：
Jewell, DP
影响因子：
27.4
作者：
van Gaalen, Floris A.;Verduijn, Willem;Toes, Rene E. M.
通讯作者：
Toes, Rene E. M.
MHC的高密度映射确定了HLA-DRB1*01：03在炎症性肠病中的共同作用和溃疡性结肠炎中的杂合优势。
影响因子：
30.8
作者：
Goyette, Philippe;Boucher, Gabrielle;Mallon, Dermot;Ellinghaust, Eva;Jostins, Luke;Huang, Hailiang;Ripke, Stephan;Gusareva, Elena S.;Annese, Vito;Hauser, Stephen L.;Oksenberg, Jorge R.;Thomsent, Ingo;Leslie, Stephen;Daly, Mark J.;Van Steen, Kristel;Duerr, Richard H.;Barrett, Jeffrey C.;McGovern, Dermot P. B.;Schumm, L. Philip;Traherne, James A.;Carrington, Mary N.;Kosmoliaptsis, Vasilis;Karsen, Tom H.;Franke, Andre;Rioux, John D.
通讯作者：
Rioux, John D.