Detection and differentiation of early hepatocellular carcinoma from cirrhosis using CT perfusion in a rat liver model
Detection and differentiation of early hepatocellular carcinoma from cirrhosis using CT perfusion in a rat liver model
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在大鼠肝脏模型中使用 CT 灌注检测早期肝细胞癌与肝硬化
DOI：
10.1016/s1499-3872(16)60148-0
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发表时间：
2016-12-01
影响因子：
3.3
通讯作者：
Jiang, Hui-Jie
中科院分区：
文献类型：
--
作者：
Li, Jin-Ping;Feng, Guang-Long;Jiang, Hui-Jie
背景：功能成像如CT灌注成像可以检测肝细胞癌（HCC）的形态学和血流动力学改变。仅观察血流动力学变化很难鉴别癌前病变和早期肝癌结节。本研究旨在探讨血流动力学参数，并评估其鉴别诊断临界值癌前和早期肝癌结节的CT灌注和受试者工作特征（ROC）currency.METHODS：雄性Wistar大鼠随机分为对照组（n=20）和实验组（n=70）。实验组用二乙基亚硝胺（DEN）诱导肝癌前和早期肝癌结节。所有存活大鼠于8 ~ 16周间断灌注扫描。通过数学解卷积模型提供肝门脉灌注（HPP）、肝动脉分数（HAF）、肝动脉灌注（HAP）、肝血容量（HBV）、肝血流量（HBF）、平均通过时间（MTT）和毛细血管表面通透性（PS）数据。采用Kruskal-Wallis检验比较3组大鼠（对照组、癌前病变组和早期肝癌组）的灌注参数，并进行ROC曲线分析。结果：HPP、HAF、HBV、HBF、MTT在3组间差异有显著性（P
BACKGROUND: Functional imaging such as CT perfusion can detect morphological and hemodynamic changes in hepatocellular carcinoma (HCC). Pre-carcinoma and early HCC nodules are difficult to differentiate by observing only their hemodynamics changes. The present study aimed to investigate hemodynamic parameters and evaluate their differential diagnostic cut-off between pre-carcinoma and early HCC nodules using CT perfusion and receiver operating characteristic (ROC) curves.METHODS: Male Wistar rats were randomly divided into control (n=20) and experimental (n=70) groups. Diethylnitrosamine (DEN) was used to induce pre-carcinoma and early HCC nodules in the experimental group. Perfusion scanning was carried out on all survival rats discontinuously from 8 to 16 weeks. Hepatic portal perfusion (HPP), hepatic arterial fraction (HAF), hepatic arterial perfusion (HAP), hepatic blood volume (HBV), hepatic blood flow (HBF), mean transit time (MTT) and permeability of capillary vessel surface (PS) data were provided by mathematical deconvolution model. The perfusion parameters were compared among the three groups of rats (control, pre-carcinoma and early HCC groups) using the Kruskal-Wallis test and analyzed with ROC curves. Histological examination of the liver tissues with hematoxylin and eosin staining was performed after CT scan.RESULTS: For HPP, HAF, HBV, HBF and MTT, there were significant differences among the three groups (P