Raver2, a new member of the hnRNP family
Raver2, a new member of the hnRNP family
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DOI：
10.1016/j.febslet.2005.07.001
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发表时间：
2005-08-15
期刊：
影响因子：
3.5
通讯作者：
Illenberger, S
中科院分区：
文献类型：
--
作者：
Kleinhenz, B;Fabienke, M;Illenberger, S
Raver2被确定为hnRNP家族的一个新成员，基于三个RNA识别基序内的序列同源性及其一般结构域组织，让人想起先前描述的raver1蛋白。像raver1，raver2包含两个假定的核定位信号和一个潜在的核输出序列，并显示在异核体检测核质穿梭。在神经胶质细胞和神经元中，raver2定位于细胞核。此外，该蛋白与多聚嘧啶束结合蛋白（PTB）相互作用，表明它可能参与PTB介导的核功能。与普遍表达的raver1相反，raver2在胚胎发育过程中表现出独特的时空表达模式，并且基本上仅限于成年小鼠的脑、肺和肾。(c)2005年欧洲生物化学学会联合会。Elsevier B.V.出版，保留所有权利。
Raver2 was identified as a novel member of the hnRNP family based on sequence homology within three RNA recognition motifs and its general domain organization reminiscent of the previously described raver1 protein. Like raver1, raver2 contains two putative nuclear localization signals and a potential nuclear export sequence, and also displays nucleocytoplasmic shuttling in a heterokaryon assay. In glia cells and neurons, raver2 localizes to the nucleus. Moreover, the protein interacts with polypyrimidine tract binding protein (PTB) suggesting that it may participate in PTB-mediated nuclear functions. In contrast to ubiquitously expressed raver1, raver2 exerts a distinct spatio-temporal expression pattern during embryogenesis and is essentially restricted to brain, lung, and kidney in the adult mouse. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.