Pregnancy Outcome in Women with Chronic Kidney Disease: A Prospective Cohort Study
Pregnancy Outcome in Women with Chronic Kidney Disease: A Prospective Cohort Study
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DOI：
10.1177/1933719110395403
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发表时间：
2011-07-01
影响因子：
2.9
通讯作者：
Chappell, Lucy C.
中科院分区：
文献类型：
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作者：
Bramham, Kate;Briley, Annette L.;Chappell, Lucy C.
目的：探讨妊娠早期合并慢性肾脏病(CKD)或蛋白尿并伴有子痫前期(PE)危险因素的妊娠结局。方法：选择确诊为慢性肾脏病(CKD)患者36例，其中CKD患者36例，孕前蛋白尿或蛋白尿均为500 mg/24小时，确诊为慢性肾脏病(CKD)患者30例，入选时间14(+0)~21(+6)周。对妊娠结局进行评估。结果：轻度CKD(孕前肌酐125mU/cr>；预约时100mU/cr/gt；n=22)有较高的先兆子痫(40%)、早产(P<0.0 5)、早产(P<0.0 5)和早产(P<0.0 5)。
Objective: To evaluate pregnancy outcome in women with chronic kidney disease (CKD) or proteinuria in early pregnancy with concomitant risk for preeclampsia (PE). Methods: Thirty-six women with CKD (Cr > 100 mu mol/L at booking or Cr > 125 mu mol/L prepregnancy or proteinuria >= 500 mg/24 hours at booking) and 30 women with proteinuria (>= 2+) and known clinical risk for PE were enrolled at 14(+0) to 21(+6) weeks. Pregnancy outcomes were assessed. Results: Women with mild CKD (prepregnancy Cr < 125 mu mol/Cr > 100 mu mol at booking; n = 22) had high rates of preeclampsia (40%), preterm delivery (