Efficient P-Chiral Biaryl Bisphosphorus Ligands for Palladium-Catalyzed Asymmetric Hydrogenation
Efficient P-Chiral Biaryl Bisphosphorus Ligands for Palladium-Catalyzed Asymmetric Hydrogenation
复制标题
用于钯催化不对称氢化的高效 P-手性联芳基双磷配体
DOI：
10.1002/cjoc.201700645
复制
发表时间：
2018-02-01
影响因子：
5.4
通讯作者：
Tang, Wenjun
中科院分区：
文献类型：
--
作者：
Jiang, Wenhao;Zhao, Qing;Tang, Wenjun
合成了一系列结构新颖的P-手性联芳基双磷配体L1-L5（BABIBOPs），首次在钯催化的β-芳基和β-烷基取代的β-酮酯的不对称氢化反应中提供了高效率.使用Pd-L3（iPr-BABIBOP）催化剂，以优异的对映选择性（高达> 99%ee）形成一系列手性羟基羧酸酯，并且在催化剂负载低至0.01mol%时产率。
A series of structurally novel P-chiral biaryl bisphosphorus ligands L1-L5 (BABIBOPs) are developed, providing high efficiency for the first time in palladium-catalyzed asymmetric hydrogenation of -aryl and -alkyl substituted -keto esters. With the Pd-L3 (iPr-BABIBOP) catalyst, a series of chiral -hydroxyl carboxylic esters are formed in excellent enantioselectivities (up to>99% ee) and yields at catalyst loading as low as 0.01 mol%.