Causal Influence of Visual Cues on Hippocampal Directional Selectivity
Causal Influence of Visual Cues on Hippocampal Directional Selectivity
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DOI：
10.1016/j.cell.2015.12.015
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发表时间：
2016-01-14
期刊：
影响因子：
64.5
通讯作者：
Mehta, Mayank R.
中科院分区：
文献类型：
--
作者：
Acharya, Lavanya;Aghajan, Zahra M.;Mehta, Mayank R.
在包括人类在内的灵长类动物中，海马神经元对视觉线索表现出选择性，但在啮齿动物中从未发现过这种情况。为了解决这个长期存在的差异，我们测量了啮齿类动物在现实世界随机觅食时的海马活动。令人惊讶的是，大约25%的神经元在视觉线索方面表现出显著的方向调制。为了分离视觉和前庭线索的贡献，我们在虚拟现实中进行了类似的测量，其中只有视觉线索是有信息的。在这里，我们发现了显著的方向调制，尽管前庭信息严重丢失，挑战了主流的方向性理论。视觉线索中角度信息量的变化在神经元和群体水平上引起了头部方向调制的相应变化。因此，视觉线索是足够的，并且在产生定向选择性海马反应中发挥可预测的因果作用。这些结果分离了海马的定向和空间选择性，并弥合了灵长类动物和啮齿动物研究之间的差距。
Hippocampal neurons show selectivity with respect to visual cues in primates, including humans, but this has never been found in rodents. To address this long-standing discrepancy, we measured hippocampal activity from rodents during real-world random foraging. Surprisingly, similar to 25% of neurons exhibited significant directional modulation with respect to visual cues. To dissociate the contributions of visual and vestibular cues, we made similar measurements in virtual reality, in which only visual cues were informative. Here, we found significant directional modulation despite the severe loss of vestibular information, challenging prevailing theories of directionality. Changes in the amount of angular information in visual cues induced corresponding changes in head-directional modulation at the neuronal and population levels. Thus, visual cues are sufficient for-and play a predictable, causal role in-generating directionally selective hippocampal responses. These results dissociate hippocampal directional and spatial selectivity and bridge the gap between primate and rodent studies.