Vitamin D supplementation and type 2 diabetes: a substudy of a randomised placebo-controlled trial in older people (RECORD trial, ISRCTN 51647438)
Vitamin D supplementation and type 2 diabetes: a substudy of a randomised placebo-controlled trial in older people (RECORD trial, ISRCTN 51647438)
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DOI：
10.1093/ageing/afp109
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发表时间：
2009-09-01
期刊：
影响因子：
6.7
通讯作者：
McPherson, Gladys C.
中科院分区：
文献类型：
--
作者：
Avenell, Alison;Cook, Jonathan A.;McPherson, Gladys C.
方法在RECORD试验中，从1999年至2002年，5292名年龄≥ 70岁且近期有过腰椎骨折的受试者被随机分为口服800 IU（20 μg）每日维生素D3、1000 mg钙（碳酸钙）或安慰剂组，随访24-62个月。该试验在英格兰和苏格兰的21个中心进行。获得苏格兰多中心研究伦理委员会和每个中心的当地研究伦理委员会的伦理批准。参与者提供了书面知情同意书。试验的全部细节和主要结果在其他地方报道[3]。
MethodsIn the RECORD trial, 5292 participants aged≥ 70 years with a recent previous osteoporotic fracture were randomised from 1999 to 2002 within a blinded, factorial design to oral 800 IU (20 μg) daily vitamin D 3, 1000 mg calcium (calcium carbonate), both, or placebo, and followed up for 24–62 months. The trial was based in 21 centres in England and Scotland. Ethical approval was obtained from the Multicentre Research Ethics Committee for Scotland and each centre's Local Research Ethics Committee. The participants gave written informed consent. Full details and main results of the trial are reported elsewhere [3].