Bio-nano interface: The impact of biological environment on nanomaterials and their delivery properties
Bio-nano interface: The impact of biological environment on nanomaterials and their delivery properties
复制标题
生物纳米界面：生物环境对纳米材料及其传递特性的影响
DOI：
10.1016/j.jconrel.2016.11.034
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发表时间：
2017-10-10
影响因子：
10.8
通讯作者：
Cheng, Jianjun
中科院分区：
文献类型：
--
作者：
Cai, Kaimin;Wang, Andrew Z.;Cheng, Jianjun
在过去的几十年里，纳米医学(NM)得到了迅速的发展，它融合了科学、工程和医学的各个交叉领域的进步。虽然少数NM的临床成功极大地改变了疾病诊断和治疗的格局，但NM仍有几个领域有待探索。其中一个领域是给药后NM与生物环境之间的复杂相互作用，以及这种相互作用如何影响NM的生物学性能。在这里，我们综述了这一课题的最新进展，并讨论了纳米材料与微观生物分子、细胞和宏观体内环境的相互作用。对生物/纳米材料界面和相互作用的完整描述将对体内性能更好的新型纳米材料的优化和从头设计产生深远的影响。(C)2017爱思唯尔B.V.保留所有权利。
The past several decades have witnessed the rapid development of nanomedicine (NM) which integrates the advancement of various interdisciplinary areas of science, engineering, andmedicine. While a fewclinical successes of NM greatly change the landscape of disease diagnosis and treatment, there are several areas of NM remaining to be explored. One such area is the complicated interactions between the NM and biological environment post administration, and how such interaction affects the biological performance of NM. Here, we review the recent progresses on this topic and discuss the interaction of NM with microscopic biomolecules, cells, and the macroscopic in vivo environment. The complete profiling of the bio/nanomaterials interface and interaction should have profound impact on the optimization and de novo design of new NM with better in vivo performance. (C) 2017 Elsevier B.V. All rights reserved.