ROS-Responsive Blended Nanoparticles: Cascade-Amplifying Synergistic Effects of Sonochemotherapy with On-demand Boosted Drug Release During SDT Process
ROS-Responsive Blended Nanoparticles: Cascade-Amplifying Synergistic Effects of Sonochemotherapy with On-demand Boosted Drug Release During SDT Process
复制标题
ROS 响应混合纳米颗粒：声化疗的级联放大协同效应与 SDT 过程中按需增强药物释放
DOI：
10.1002/adhm.201900720
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发表时间：
2019
影响因子：
10
通讯作者：
Zong Yujin
中科院分区：
文献类型：
--
作者：
Wu Pengying;Dong Wei;Guo Xuyan;Qiao Xiaoyang;Guo Shifting;Zhang Lei;Wan Mingxi;Zong Yujin
声动力疗法（SDT）不仅具有比光刺激疗法更大的组织穿透深度，而且还可以触发快速药物释放以实现协同声化学疗法。在这里，活性氧（ROS）响应性IR 780/PTL纳米颗粒（NP）是通过自组装设计的，其含有ROS可裂解的硫代缩酮接头（TL）以促进紫杉醇（PTX）在SDT期间的释放。在超声（US）刺激下，IR 780/PTL-NPs产生大量ROS，不仅诱导人胶质瘤（U87）细胞凋亡，还通过分解ROS敏感的TL促进PTX释放。在U87荷瘤小鼠模型中，IR 780/PTL-NPs在超声照射后以受控方式在靶位点释放药物，显著抑制肿瘤生长并诱导肿瘤组织凋亡，无明显毒性。综上所述，IR 780/PTL-NP是一种用于声化学疗法的新型平台，可以在SDT期间控制化疗药物的时空释放。
Sonodynamic therapy (SDT) not only has greater tissue‐penetrating depth compared to photo‐stimulated therapies, but also can also trigger rapid drug release to achieve synergistic sonochemotherapy. Here, reactive oxygen species (ROS)‐responsive IR780/PTL‐ nanoparticles (NPs) are designed by self‐assembly, which contain ROS‐cleavable thioketal linkers (TL) to promote paclitaxel (PTX) release during SDT. Under ultrasound (US) stimulation, IR780/PTL‐NPs produce high amounts of ROS, which not only induces apoptosis in human glioma (U87) cells but also boosts PTX released by decomposing the ROS‐sensitive TL. In the U87 tumor‐bearing mouse model, the IR780/PTL‐NPs releases the drug at the target sites in a controlled manner upon US irradiation, which significantly inhibits tumor growth and induces apoptosis in the tumor tissues with no obvious toxicity. Taken together, the IR780/PTL‐NPs are a novel platform for sonochemotherapy, and can control the spatio‐temporal release of chemotherapeutic drugs during SDT.