Ongoing activity in peripheral nerves: The physiology and pharmacology of impulses originating from a neuroma ☆
Ongoing activity in peripheral nerves: The physiology and pharmacology of impulses originating from a neuroma ☆
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DOI：
10.1016/0014-4886(74)90197-6
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发表时间：
1974-06
影响因子：
5.3
通讯作者：
P. Wall;M. Gutnick
中科院分区：
文献类型：
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作者：
P. Wall;M. Gutnick
在大鼠中，切断坐骨神经，将其拉入一端密封的聚乙烯管中，并允许神经瘤在腔室中生长。活动在背根和腹根终止于神经瘤进行了检查9天和4个月后的部分。一小部分起源于神经瘤的有髓传入纤维携带着稳定的持续不断的神经冲动。许多精细的端子被轻微的机械变形所激发。神经瘤中的细芽是可电兴奋的。持续的传入屏障高度依赖于血流。在短暂的逆行性破伤风侵入活性纤维后，它会在很长一段时间内消失。这表明从外周神经刺激获得的一些疼痛缓解可能具有外周机制而不是中枢机制。在一组神经纤维的齐射和神经瘤中其他组纤维的活动之间没有检测到兴奋抑制相互作用的迹象。α活性交感胺，去甲肾上腺素，兴奋正在进行的活动，而β剂，异丙肾上腺素，没有兴奋作用。这表明α阻滞剂可能有助于测试交感神经系统是否参与特定的疼痛。
In rats, the sciatic nerve was cut, drawn into a polythene tube with one end sealed, and a neuroma allowed to develop in the chamber. Activity in the dorsal and ventral roots terminating in the neuroma was examined between 9 days and 4 months after the section. A fraction of the small myelinated afferent fibers originating in the neuroma were carrying a steady ongoing barrage of nerve impulses. Many of the fine terminals were excited by slight mechanical distortion. The fine sprouts in the neuroma were electrically excitable. The ongoing afferent barrage was highly dependent on blood flow. It was abolished for long periods of time after a brief antidromic tetanus had invaded the active fibers. This suggests that some of the pain relief obtained from peripheral nerve stimulation may have a peripheral rather than a central mechanism. No signs of excitatory on inhibitory interaction were detected between volleys in one group of nerve fibers and the activity in other groups of fibers in the neuroma. Alpha active sympathetic amines, noradrenaline, excited the ongoing activity while beta agents, isoprenaline, had no excitatory effect. This suggests that alpha blocking agents might be useful to test if the sympathetic system is involved in particular pains.