CATECHOLAMINERGIC EFFECTS ON NEURONAL-ACTIVITY RELATED TO A DELAYED-RESPONSE TASK IN MONKEY PREFRONTAL CORTEX
CATECHOLAMINERGIC EFFECTS ON NEURONAL-ACTIVITY RELATED TO A DELAYED-RESPONSE TASK IN MONKEY PREFRONTAL CORTEX
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DOI：
10.1152/jn.1990.63.6.1385
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发表时间：
1990-06-01
影响因子：
2.5
通讯作者：
KUBOTA, K
中科院分区：
文献类型：
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作者：
SAWAGUCHI, T;MATSUMURA, M;KUBOTA, K
1.采用电离子透入技术，研究了多巴胺（DA）和去甲肾上腺素（NA）对日本猕猴前额叶皮层（PFC）延迟反应（DR）任务相关神经元活动的影响。DR任务通过将手柄旋转到中心区域来启动，并且由七个不同的时间段组成：初始等待期为0.3 s，预处理期为1 s（中央绿色灯），提示周期为1秒（左灯或右灯），延迟时间为4 s，启动时间为1 s（中心的红灯;手柄旋转到左区或右区）、保持时间段（手柄在左区或右区保持0.3秒）和最终奖励时间段。2.共116个神经元与DR任务相关。他们表现出增加活动在precue期间（precue类型，n = 19），在提示和去期间（提示/GO类型，n = 17），去期间（GO类型，n = 16），并在延迟期间（延迟类型，n = 64）。延迟型神经元进一步分为差分神经元（n = 33），其中延迟相关活动的幅度之间的左，右线索试验显着不同，和非差分神经元（n = 31）。一些延迟型神经元在提示（n = 26），go（n = 27）或提示和go（n = 11）期间也表现出活动增加。3. DA或NA，应用离子电渗电流为50 nA，诱导增加或减少的反应，在大多数DR任务相关的神经元。DA使大多数的Cue/GO-（16/17）、GO-（13/16）和Delay型神经元（49/64）的活动增加，NA使大多数的Precue-（13/19）和非分化Delay型神经元（25/31）的活动减少。因此，不同类型的DR任务相关神经元对DA和NA表现出不同的反应。4.在提示/GO-，GO-，和/或延迟型神经元，DA增加相关的提示，去，和延迟期的活动比它增加的背景活动更强烈。结果，比率[即，与线索、go和延迟期相关的活动与背景活动的信噪比（S/N）增加。5.在Precue型或非微分延迟型神经元，NA降低背景活动更强烈比它降低活动在precue或延迟期间。（400字处截断摘要）
1. Using iontophoretic techniques, we investigated the effects of dopamine (DA) and noradrenaline (NA) on neuronal activity related to a delayed response (DR) task in the prefrontal cortex (PFC) of the Japanese macaque monkeys. The DR task was initiated by rotation of a handle to a central zone and consisted of seven distinct time periods: an initial waiting period of 0.3 s, a precue period of 1 s (a central green lamp), a cue period of 1 s (left or right lamp), a delay period of 4 s, a go period of 1 s (red lamp in the center; rotation of the handle to either the left or right zone), a hold period (holding of the handle in either the left or right zone for 0.3 s), and a final reward period. 2. A total of 116 neurons were DR task related. They showed increases in activity during the precue period (Precue-types, n = 19), during both the cue and go periods (Cue/GO-types, n = 17), the go period (GO-types, n = 16), and during the delay period (Delay-types, n = 64). The Delay-type neurons were further divided into differential neurons (n = 33), for which the magnitude of the delay-related activity differed significantly between left- and right-cue trials, and nondifferential neurons (n = 31). Some of the Delay-type neurons also showed increases in activity during the cue (n = 26), go (n = 27), or both the cue and go periods (n = 11). 3. DA or NA, applied iontophoretically with a current of 50 nA, induced increased or decreased responses in most of the DR task-related neurons. DA increased activity of most of the Cue/GO-(16/17), GO-(13/16), and Delay-type neurons (49/64), and NA decreased activity of most of the Precue- (13/19) and non-differential Delay-type neurons (25/31). Thus different types of DR task-related neurons showed different responses to DA and NA. 4. In Cue/GO-, GO-, and/or Delay-type neurons, DA increased the activity related to the cue, go, and delay periods more strongly than it increased background activity. As a result, the ratio [i.e., signal-to-noise (S/N) ratio] of activity related to the cue, go, and delay periods to background activity was increased. 5. In Precue-type or nondifferential Delay-type neurons, NA decreased background activity more strongly than it decreased activity during the precue or delay period.(ABSTRACT TRUNCATED AT 400 WORDS)