EFFECT OF EXTRAVASCULAR PRESSURE-GRADIENTS ON CAPILLARY FLUID EXCHANGE
EFFECT OF EXTRAVASCULAR PRESSURE-GRADIENTS ON CAPILLARY FLUID EXCHANGE
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DOI：
10.1016/0025-5564(86)90114-8
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发表时间：
1986-10-01
影响因子：
4.3
通讯作者：
GROSS, JF
中科院分区：
文献类型：
--
作者：
FLEISCHMAN, GJ;SECOMB, TW;GROSS, JF
建立了一个数学模型，研究了血管外空间压力梯度对毛细血管液体交换的影响。Starling的假说描述了通过毛细血管壁的流体运输，并且D '' Arcy '定律控制组织中的流动。使用生理上合理的值的壁和组织的导水率和其他参数，它表明，组织的静水压力是不均匀的整个组织空间。背景压力的最大偏差发生在毛细管附近，并且偏差的幅度随着两个电导率的比率的增加而增加。该模型还表明，流体交换行为被修改的存在下，其他毛细管。这种毛细管-毛细管相互作用受电导率比、毛细管接近度和现有毛细管数量的影响。
A mathematical model is developed to examine the effect of pressure gradients in the extravascular space on fluid exchange from capillaries. Starling''s hypothesis describes fluid transport through the capillary wall, and D''Arcy''s law governs flow in the tissue. Using physiologically reasonable values for the wall and tissue hydraulic conductivities and other parameters, it is shown that the tissue hydrostatic pressure is not uniform throughout the tissue space. The greatest deviations from the background pressure occur near the capillary, and the magnitude of deviations increases with increasing ratios of the two conductivities. The model also shows that the fluid exchange behavior is modified by the presence of other capillaries. This capillary-capillary interaction is influenced by the ratio of conductivities, capillary proximity, and the number of existing capillaries.