Mechanisms of neural organization and rhythmogenesis during hippocampal and cortical ripples.
Mechanisms of neural organization and rhythmogenesis during hippocampal and cortical ripples.
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海马和皮质波纹期间的神经组织和节律发生机制。
DOI：
10.1098/rstb.2019.0237
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
English,DanielF
中科院分区：
文献类型：
--
作者：
McKenzie,Sam;Nitzan,Noam;English,DanielF
在过去的三十年里，波纹期间的神经活动引起了极大的理论和实验关注。也许这样感兴趣的一个原因是，涟漪发生在安静的清醒时刻和睡眠中，当我们反思和梦见刚刚发生的事情和我们预计接下来会发生什么的时候。研究人员希望，通过了解这种“线下”活动，可以更深入地了解思考、计划和睡眠的目的。这篇综述着重于神经元在这些高频事件中的组织机制。在对涟漪的研究中，已经出现了更广泛的原理，这些原理与控制神经活动的内在神经属性、网络拓扑和突触可塑性有关。因此，涟漪是研究神经网络的性质如何与神经动力学相关的一个极好的模型。这篇文章是西奥·墨菲会议专题《记忆重新激活：重播过去、现在和未来的事件》的一部分。
Neural activity during ripples has attracted great theoretical and experimental attention over the last three decades. Perhaps one reason for such interest is that ripples occur during quiet waking moments and during sleep, times when we reflect and dream about what has just occurred and what we expect to happen next. The hope is that understanding such ‘offline’ activity may yield insights into reflection, planning, and the purposes of sleep. This review focuses on the mechanisms by which neurons organize during these high-frequency events. In studying ripples, broader principles have emerged that relate intrinsic neural properties, network topology and synaptic plasticity in controlling neural activity. Ripples, therefore, serve as an excellent model for studying how properties of a neural network relate to neural dynamics.This article is part of the Theo Murphy meeting issue ‘Memory reactivation: replaying events past, present and future’.