ENDOGENOUS D-SERINE IN RAT-BRAIN - N-METHYL-D-ASPARTATE RECEPTOR-RELATED DISTRIBUTION AND AGING
ENDOGENOUS D-SERINE IN RAT-BRAIN - N-METHYL-D-ASPARTATE RECEPTOR-RELATED DISTRIBUTION AND AGING
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DOI：
10.1111/j.1471-4159.1993.tb03219.x
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发表时间：
1993-02-01
影响因子：
4.7
通讯作者：
TAKAHASHI, K
中科院分区：
文献类型：
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作者：
HASHIMOTO, A;NISHIKAWA, T;TAKAHASHI, K
最近，大量的游离D-丝氨酸已被证明在大鼠脑中，虽然它一直被认为是D-氨基酸是罕见的哺乳动物。内源性D-丝氨酸的解剖分布和年龄相关的变化已在这里检查，以了解其生理功能。游离D-丝氨酸仅存在于大脑中，从出生到出生后至少86周持续高含量。脑内D-丝氨酸的区域变化和生后变化与N-甲基-D-天冬氨酸（NMDA）型兴奋性氨基酸受体的变化密切相关。由于D-丝氨酸通过选择性刺激NMDA受体的士的宁不敏感的甘氨酸位点而增强NMDA受体介导的传递，因此提出D-丝氨酸是哺乳动物脑中甘氨酸位点的内在配体的新候选者。
Recently, a substantial amount of free D-serine has been demonstrated in rat brain, although it has long been presumed that D-amino acids are uncommon in mammals. The anatomical distribution and age-related changes in endogenous D-serine have been examined here to obtain insight into its physiological functions. Free D-serine exclusively occurs in brains, with a persistent high content from birth to at least 86 postnatal weeks. The patterns of the regional variations and the postnatal changes in brain D-serine are closely correlated with those of the N-methyl-D-aspartate (NMDA)-type excitatory amino acid receptor. BecaUSe D-serine potentiates NMDA receptor-mediated transmission by selective stimulation of the strychnine-insensitive glycine site of the NMDA receptor, it is proposed that D-serine is a novel candidate as an intrinsic ligand for the glycine site in mammalian brain.