Association of NE, leptin, and 5-HT with electrophysiological parameters in patients with primary premature ejaculation
Association of NE, leptin, and 5-HT with electrophysiological parameters in patients with primary premature ejaculation
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DOI：
10.1111/andr.12773
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发表时间：
2020-03-02
期刊：
影响因子：
4.5
通讯作者：
Song, Ninghong
中科院分区：
文献类型：
--
作者：
Xia, Jiadong;Zhang, Qijie;Song, Ninghong
目的探讨血清去甲肾上腺素(NE)、瘦素(Leptin)和5-羟色胺(5-HT)在原发性早泄(PPE)中的作用及其与阴茎交感神经皮肤反应(PSSR)的关系。方法对2016年9月至2019年1月入选的57例PPE患者和42例健康男性进行血清NE、Leptin和5-羟色胺水平、阴道内射精潜伏期(IELT)和早泄诊断工具(PEDT)评分的比较。结果与健康男性比较，PPE患者血清瘦素、NE均显著升高(P=0.003，P=0.005)，5-羟色胺显著降低(P=0.002)。血清瘦素、去甲肾上腺素和5-羟色胺与PPE的诊断、PSSR波幅和潜伏期显著相关。与单一血清指标相比，NE/5-HT和Leptin/5-HT与PSSR波幅(r=.8377，Pr=.9323，P<；.001)和潜伏期(r=-.8058，Pr=-.8901，P<；.001)均有较强的相关性。结论PPE患者血清Leptin、NE和5-HT水平与对照组有显著差异，支持PPE存在交感神经系统过度活跃的假说。此外，瘦素/5-羟色胺比值可作为反映SNS活动性和预测PPE患者未来治疗反应的理想指标。
Objective To investigate the possible role of serum norepinephrine (NE), leptin, and 5-hydroxytryptamine (5-HT) and their correlations with sympathetic skin response located in the penis (PSSR) in primary premature ejaculation (PPE).Methods We compared the serum level of NE, leptin, and 5-HT, intravaginal ejaculatory latency time (IELT) and the premature ejaculation diagnostic tool (PEDT) scores between 57 PPE patients and 42 healthy control men as controls, who were recruited between September 2016 and January 2019. Additionally, the amplitude and latency of PSSR were measured and compared between the two groups.Results Compared with healthy men, both leptin and NE increased significantly in PPE patients (P = .003, P = .005), while serum 5-HT remarkably decreased (P = .002). Serum leptin, NE, and 5-HT were significantly correlated with the diagnosis of PPE, PSSR amplitude, and latency. Moreover, compared with single serum indicator, NE/5-HT and leptin/5-HT had a stronger correlation with both PSSR amplitude (r = .8377, P r = .9323, P < .001, respectively) and latency (r = -.8058, P r = -.8901, P < .001, respectively).Conclusion Significant differences in leptin, NE, and 5-HT are observed between PPE patients and the controls, which supports the hypothesis of hyperactive sympathetic nerve system (SNS) in PPE. Additionally, leptin/5-HT ratio may serve as an ideal indicator for reflecting SNS activity and predicting treatment response in PPE patients in the future.