Effects of Nicardipine on Pulmonary and Systemic Vascular Reactivity to Oxygen in Patients with Pulmonary Hypertension Secondary to Chronic Obstructive Lung Disease
Effects of Nicardipine on Pulmonary and Systemic Vascular Reactivity to Oxygen in Patients with Pulmonary Hypertension Secondary to Chronic Obstructive Lung Disease
复制标题
尼卡地平对继发于慢性阻塞性肺病的肺动脉高压患者肺和全身血管对氧反应性的影响
DOI：
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发表时间：
1991
影响因子：
3
通讯作者：
A. Arnaud
中科院分区：
文献类型：
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作者：
A. Saadjian;F. Philip;Bun Hot;M. Reynaud;A. Durand;S. Lévy;A. Arnaud
总结：我们比较了尼卡地平和安慰剂对10例慢性阻塞性肺疾病继发性肺动脉高压患者肺循环和体循环对不同吸入分数氧浓度（FiO 2）的反应的急性影响。肺动脉和股动脉插管后，在输注生理盐水和尼卡地平（0.06 mg/kg/min）期间，随机给予含15、21和30% O2的气体混合物各20 min。血浆尼卡地平水平维持在30 ng/ml。在尼卡地平输注期间，心脏指数（CI）显著高于安慰剂输注期间（+20%，p < 0.05），而平均肺动脉压（MPAP）无变化。尼卡地平治疗期间肺阻力也显著降低（-20%）。未观察到动脉或混合静脉O2含量变化。平均动脉压（MAP）和全身阻力显着降低尼卡地平。在安慰剂输注期间，吸入高氧混合物后动脉压显着下降;在尼卡地平期间没有观察到这一点。与体循环相反，肺循环对不同FiO水平的反应不受尼卡地平的影响。
Summary: We compared the acute effects of nicardipine and a placebo on the response of pulmonary and systemic circulation to different inspiratory fractional concentrations of O2 (FiO2) in 10 patients with pulmonary hypertension secondary to chronic obstructive lung disease. After catheterization of the pulmonary and femoral arteries, gas mixtures containing 15, 21, and 30% O2 were randomly administered for 20 min each during infusion of saline and then nicardipine (0.06 mg/kg/min). Plasma nicardipine level was maintained at 30 ng/ml. During nicardipine infusion, cardiac index (CI) was significantly higher (+20%, p < 0.05) than during placebo infusion, with no change in mean pulmonary artery pressure (MPAP). Pulmonary resistances also decreased significantly (– 20%) during nicardipine. No change in arterial or mixed venous O2 contents was noted. Mean arterial pressure (MAP) and systemic resistances decreased significantly with nicardipine. Inhaling a hyperoxic mixture was followed by a significant decrease in arterial pressure during placebo infusion; this was not observed during nicardipine. In contrast with systemic circulation, the response of the pulmonary circulation to different FiO, levels was unaffected by nicardipine.