Prognostic factors for conjunctival melanoma: a study in ethnic Chinese patients
Prognostic factors for conjunctival melanoma: a study in ethnic Chinese patients
复制标题
DOI：
10.1136/bjophthalmol-2014-305730
复制
发表时间：
2015-07-01
影响因子：
4.1
通讯作者：
Guo, Jun
中科院分区：
文献类型：
--
作者：
Sheng, Xinan;Li, Siming;Guo, Jun
背景/目的在结膜黑色素瘤患者中，手术是治疗的首选，但尚未建立标准的辅助治疗方法。在这项研究中，我们评估了华人结膜黑色素瘤患者的预后因素。方法回顾性分析53例经病理证实的结膜黑色素瘤患者的人口学资料、已知（已发表）预后因素、BRAF和KIT基因突变、治疗策略和预后。分别采用Kaplan-Meier法和Cox比例风险模型对与生存相关的因素进行单因素和多因素分析。结果对50例患者的单因素分析显示，较高的T期（p=0.041）、较大的肿瘤厚度（p=0.006）、局部切除（p=0.033）和未进行辅助治疗（p=0.006）与较差的无复发生存期（RFS）和无转移生存期（MFS）相关。累及象限越多的患者MFS也越差（p=0.039），而T分期越高（p=0.039）
Background/objective In patients with conjunctival melanomas, surgery is the first choice of treatment, but no standard adjuvant therapy has been established. In this study, we evaluated prognostic factors for conjunctival melanoma in ethnic Chinese patients.Methods Demographic data, known (published) prognostic factors, BRAF and KIT gene mutations, treatment strategies and outcomes were reviewed in 53 patients with pathologically confirmed conjunctival melanomas. Univariate and multivariate analyses of factors associated with survival were performed by the Kaplan-Meier method and a Cox proportional hazard model, respectively.Results Univariate analyses for 50 patients in whom data were available showed that a higher T stage (p=0.041), greater tumour thickness (p=0.006), local resection (p=0.033) and no adjuvant therapy (p=0.006) were associated with a worse recurrence-free survival (RFS) and metastasis-free survival (MFS). Patients with more involved quadrants also had worse MFS (p=0.039), while a higher T stage (p