Clinical factors associated with calcific aortic valve disease
Clinical factors associated with calcific aortic valve disease
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DOI：
10.1016/s0735-1097(96)00563-3
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发表时间：
1997-03-01
影响因子：
24
通讯作者：
Otto, CM
中科院分区：
文献类型：
--
作者：
Stewart, BF;Siscovick, D;Otto, CM
目标。本研究的目的是确定老年人主动脉硬化和狭窄的患病率，并确定与退行性主动脉瓣疾病相关的临床因素。一些证据表明，退行性主动脉瓣疾病不是衰老的必然结果，可能与特定的临床因素有关。在5201名大于或等于65岁的心血管健康研究对象中，采用逐步logistic回归分析评估超声心动图检测的主动脉硬化或狭窄与动脉粥样硬化临床危险因素之间的关系。在整个研究队列中，26%的患者存在主动脉瓣硬化，2%的患者存在主动脉瓣狭窄；在大于或等于75岁的受试者中，37%出现硬化症，2.6%出现狭窄。与退行性主动脉瓣疾病相关的独立临床因素包括年龄（年龄每增加10年风险增加两倍）、男性性别（风险增加两倍）、吸烟（风险增加35%）和高血压史（风险增加20%），其他重要因素包括身高、高脂蛋白(a)和低密度脂蛋白胆固醇水平。与主动脉硬化和狭窄相关的临床因素可以确定，并且与动脉粥样硬化的危险因素相似。(C) 1997年由美国心脏病学会发布。
Objectives. The aim of this study was to determine the prevalence of aortic sclerosis and stenosis in the elderly and to identify clinical factors associated with degenerative aortic valve disease.Background. Several lines of evidence suggest that degenerative aortic valve disease is not an inevitable consequence of aging and may be associated with specific clinical factors.Methods. In 5,201 subjects greater than or equal to 65 years of age enrolled in the Cardiovascular Health Study, the relation between aortic sclerosis or stenosis identified on echocardiography and clinical risk factors for atherosclerosis was evaluated by using stepwise logistic regression analysis.Results. Aortic value sclerosis was present in 26% and aortic valve stenosis in 2% of the entire study cohort; in subjects greater than or equal to 75 years of age, sclerosis was present in 37% and stenosis in 2.6%. Independent clinical factors associated with degenerative aortic valve disease included age (twofold increased risk for each 10-year increase in age), male gender (twofold excess risk), present smoking (35% increase in risk) and a history of hypertension (20% increase in risk), Other significant factors included height and high lipoprotein(a) and low density lipoprotein cholesterol levels.Conclusions. Clinical factors associated with aortic sclerosis and stenosis can be identified and are similar to risk factors for atherosclerosis. (C) 1997 by the American College of Cardiology.