IL-33 family members and asthma - bridging innate and adaptive immune responses.
IL-33 family members and asthma - bridging innate and adaptive immune responses.
复制标题
DOI：
10.1016/j.coi.2010.10.006
复制
发表时间：
2010-12
影响因子：
7
通讯作者：
Lloyd CM
中科院分区：
文献类型：
--
作者：
Lloyd CM
IL-33作为孤儿Th 2相关受体ST 2的配体的发现揭示了该途径的整个不同途径。虽然ST 2作为Th 2细胞和肥大细胞活性的标志物的细胞外功能已经得到了很好的定义，但IL-33调节、核功能和分泌的复杂性才刚刚实现。ST 2的充分记录的表达模式已经确定了IL-33/ST 2轴在经典的Th 2细胞和肥大细胞驱动的哮喘和过敏反应的发病机制中的作用。然而，通过环境或内源性触发物诱导IL-33表达现在表明该途径在感染、炎症和组织损伤期间具有更广泛的作用。
The discovery of IL-33 as the ligand for the orphan Th2 associated receptor ST2 has uncovered a whole range of different avenues for this pathway. Although the extracellular functions of ST2 as a marker for Th2 cell and mast cell activity were well defined, the complexities of IL-33 regulation, nuclear function and secretion are only just being realised. The well documented expression pattern of ST2 has identified a role for the IL-33/ST2 axis in the classical Th2 cell and mast cell driven pathogenesis of asthma and anaphylaxis. However, the induction of IL-33 expression by environmental or endogenous triggers now suggests a wider role for the pathway during infection, inflammation and tissue damage.
登录
查看更多内容
影响因子：
5.4
作者：
Mayuzumi, Nobuyasu;Matsushima, Hironori;Takashima, Akira
通讯作者：
Takashima, Akira
DOI：
10.1073/pnas.0812690106
发表时间：
2009-06-02
影响因子：
11.1
作者：
Cayrol, Corinne;Girard, Jean-Philippe
通讯作者：
Girard, Jean-Philippe
影响因子：
5
作者：
Iikura, Motoyasu;Suto, Hajime;Nakae, Susumu
通讯作者：
Nakae, Susumu
影响因子：
4.4
作者：
Kurowska-Stolarska, Mariola;Kewin, Pete;Xu, Damo
通讯作者：
Xu, Damo
影响因子：
14.2
作者：
Allakhverdi, Zoulfia;Comeau, Michael R.;Delespesse, Guy
通讯作者：
Delespesse, Guy