Neuroproteomics as a promising tool in Parkinson's disease research.
Neuroproteomics as a promising tool in Parkinson's disease research.
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神经蛋白质组学是帕金森病研究中很有前途的工具。
DOI：
10.1007/s00702-008-0070-3
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Götz,Jürgen
中科院分区：
文献类型：
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作者：
Pienaar,IlseS;Daniels,WilliamMU;Götz,Jürgen
尽管对帕金森病（PD）的研究数量众多，但其有效的诊断和治疗仍不令人满意。因此，对最佳治疗方法的不懈探索仍在继续。神经蛋白质组学的出现，以其复杂的技术和无偏见的能力，定量蛋白质，提供了一种方法，与神经退行性变相关的神经元的变化进行研究。神经蛋白质组学是建立疾病相关蛋白质谱的新兴工具，同时也对这些蛋白质如何相互作用和进行翻译后修饰有了更深入的了解。此外，由于生物信息学的进步，人们对它们的功能特征有了更深入的了解。在这篇综述中，我们首先总结了最突出的蛋白质组学技术，然后讨论了在帕金森病的神经蛋白质组学的快速增长领域的主要进展。最终，人们希望这项技术的应用将导致PD的症状前诊断，并确定风险因素和新的治疗靶点，从而可以进行药物干预。
Despite the vast number of studies on Parkinson’s disease (PD), its effective diagnosis and treatment remains unsatisfactory. Hence, the relentless search for an optimal cure continues. The emergence of neuroproteomics, with its sophisticated techniques and non-biased ability to quantify proteins, provides a methodology with which to study the changes in neurons that are associated with neurodegeneration. Neuroproteomics is an emerging tool to establish disease-associated protein profiles, while also generating a greater understanding as to how these proteins interact and undergo post-translational modifications. Furthermore, due to the advances made in bioinformatics, insight is created concerning their functional characteristics. In this review, we first summarize the most prominent proteomics techniques and then discuss the major advances in the fast-growing field of neuroproteomics in PD. Ultimately, it is hoped that the application of this technology will lead towards a presymptomatic diagnosis of PD, and the identification of risk factors and new therapeutic targets at which pharmacological intervention can be aimed.