A NEW FUSED TRANSCRIPT IN PHILADELPHIA-CHROMOSOME POSITIVE ACUTE LYMPHOCYTIC-LEUKEMIA
A NEW FUSED TRANSCRIPT IN PHILADELPHIA-CHROMOSOME POSITIVE ACUTE LYMPHOCYTIC-LEUKEMIA
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DOI：
10.1038/330386a0
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发表时间：
1987-11-26
期刊：
影响因子：
64.8
通讯作者：
CROCE, CM
中科院分区：
文献类型：
--
作者：
FAINSTEIN, E;MARCELLE, C;CROCE, CM
超过 90% 的慢性粒细胞白血病 (CML) 患者和 10% 的急性淋巴细胞白血病 (ALL) 患者的白血病细胞携带 t(9:22) (q34:qll) 易位，从而产生费城染色体 (Ph1)。在 CML 中，theabl 基因从 9 号染色体易位到 22 号染色体上 thebcr 基因的中心，这导致产生嵌合 bcr-ablRNA，翻译成相对分子质量 (Mr) 210,000 (210K) 的蛋白质。我们的数据表明在 ALLablis 中易位到 thebcr 基因的 5' 区域。其结果是融合转录物的表达，其中bcris的第一个外显子与第二个ablexon连接。该转录本编码 190K 蛋白激酶。
The leukaemic cells of more than 90% of chronic myelogenous leukaemia (CML) patients and of 10% of acute lymphocytic leukaemia (ALL) patients carry the t(9:22) (q34:qll) translocation which generates the Philadelphia chromosome (Ph1). In CML theablgene is translocated from chromosome 9 to the centre of thebcrgene on chromosome 22 and this results in production of chimaericbcr-ablRNA translated into a protein of relative molecular mass (Mr) 210,000 (210K). Our data indicate that in ALLablis translocated into the 5' region of thebcrgene. The consequence of this is the expression of a fused transcript in which the first exon ofbcris linked to the secondablexon. This transcript encodes a 190K protein kinase.