Effects of dietary glucosylceramide on dermatitis in atopic dermatitis model mice
Effects of dietary glucosylceramide on dermatitis in atopic dermatitis model mice
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DOI：
10.1002/ejlt.200900268
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发表时间：
2010-07
影响因子：
2.7
通讯作者：
J. Ono;M. Kinoshita;K. Aida;M. Tamura;M. Ohnishi
中科院分区：
文献类型：
--
作者：
J. Ono;M. Kinoshita;K. Aida;M. Tamura;M. Ohnishi
在小鼠模型中研究了膳食植物和酵母中的主要鞘脂--葡萄糖神经酰胺（glucosylceramide）对特应性皮炎（AD）样症状的影响。7周后喂养的饮食含有玉米葡糖神经酰胺，血浆IgE水平变得显着降低，相反，白细胞介素（IL）-12，诱导细胞免疫的水平，成为显着高于AD小鼠比对照组。然而，在玉米葡糖神经酰胺饲喂组中皮肤部分的鞘脂成分不含植物来源的鞘氨醇碱，例如8-不饱和鞘氨醇碱。本研究结果表明，膳食植物葡萄糖神经酰胺通过调节Th 1/Th 2平衡来预防AD模型小鼠的AD样症状。实际应用：膳食植物和酵母葡糖神经酰胺已显示通过调节辅助T细胞Th 1/Th 2平衡来抑制AD模型小鼠中的AD样症状。葡萄糖神经酰胺能够预防AD，并可用于护肤产品。
The effects of dietary plant and yeast cerebroside (glucosylceramide), a major sphingolipid in plants and yeast, on atopic dermatitis (AD) like symptoms were investigated in a mouse model. After 7 wk of feeding with a diet containing maize glucosylceramide, plasma IgE levels became significantly lower and in contrast, the levels of interleukin (IL)-12, which induces cellular immunity, became significantly higher in the AD mice than in the controls. However, the sphingolipid constituents of the skin fraction in the maize glucosylceramide fed group did not contain sphingoid bases of plant origin, such as 8-unsaturated sphingoid bases. The results of the present study indicated that dietary plant glucosylceramide prevented AD-like symptoms in AD model mice via regulation of Th1/Th2 balance. Practical applications: Dietary plant and yeast glucosylceramides have been shown to suppress AD-like symptoms in AD model mice via regulation of helper T-cell Th1/Th2 balance. Glucosylceramide are capable of preventing AD and may be useful in skincare products.