Involvement of miR-126 in autoimmune disorders.
Involvement of miR-126 in autoimmune disorders.
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DOI：
10.1186/s12948-018-0089-4
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发表时间：
2018
期刊：
影响因子：
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通讯作者：
Gangemi S
中科院分区：
文献类型：
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作者：
Casciaro M;Di Salvo E;Brizzi T;Rodolico C;Gangemi S
micro-RNA代表了一个大家族的小的非condign核糖核酸分子;特别是microRNA-126是这个家族的重要成员，并在许多人类细胞中表达，如心肌细胞，内皮细胞和肺细胞。一些研究表明miR-126在癌症中的作用，但最近在确定miR-126调节免疫相关疾病的作用方面也取得了重大进展;在不久的将来，它们可能成为诊断生物标志物或治疗靶点。本文就miR-126在自身免疫性疾病中的作用进行综述，以期为临床治疗提供新的思路。根据文献，可以得出结论，miRNA，特别是miR-126，参与许多病理学，并且它们的表达水平在自身免疫性疾病中增加，因为它们干扰所涉及的蛋白质的转录。由于microRNA可以从几种生物来源中检测到，因此它们可能是有吸引力的潜在生物标志物，用于诊断，预后，疾病活动和各种疾病的严重程度。事实上，一旦证实了miR-126参与自身免疫性疾病，人们就推测它可以作为一种有前途的生物标志物。这些发现暗示miR-126在导致自身免疫性疾病的发展和持续的许多途径中具有中心作用。它的关键作用使这种microRNA成为自身免疫的潜在治疗靶点。尽管miR-126在多种免疫相关疾病中发挥着重要作用，但其分子机制仍需进一步研究，这些新研究的最终目标可能是通过创造新的靶向治疗来阻断或预防疾病的发生。
Micro-RNA represent a great family of small non-condign ribonucleic acid molecules; in particular microRNA-126 is an important member of this family and is expressed in many human cells such as cardiomyocytes, endothelial and lung cells. Some studies have shown the implication of miR-126 in cancer, but recently significant progresses have also been made in determining the role of miR-126 regulating immune-related diseases; probably, in a near future, they could potentially serve as diagnostic biomarkers or therapeutic targets. The purpose of this review is to investigate the role of miR-126 in autoimmune diseases, so as to offer innovative therapies. According literature, it was concluded that miRNAs, especially miR-126, are involved in many pathologies and that their expression levels increase in autoimmune diseases because they interfere with the transcription of the proteins involved. Since microRNAs can be detected from several biological sources, they may be attractive as potential biomarkers for the diagnosis, prognosis, disease activity and severity of various diseases. In fact, once confirmed the involvement of miR-126 in autoimmune diseases, it was speculated that it could be used as a promising biomarker. These discovers implicate that miR-126 have a central role in many pathways leading to the development and sustain of autoimmune diseases. Its key role make this microRNA a potential therapeutic target in autoimmunity. Although miR-126 relevant role in several immune-related diseases, further studies are needed to clear its molecular mechanisms; the final step of these novel researches could be the blockage or the prevention of the diseases onset by creating of new targeted therapy.