Feasibility, Acceptability, and Efficacy of Home-Based Transcranial Direct Current Stimulation on Pain in Older Adults with Alzheimer's Disease and Related Dementias: A Randomized Sham-Controlled Pilot Clinical Trial.
Feasibility, Acceptability, and Efficacy of Home-Based Transcranial Direct Current Stimulation on Pain in Older Adults with Alzheimer's Disease and Related Dementias: A Randomized Sham-Controlled Pilot Clinical Trial.
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DOI：
10.3390/jcm12020401
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发表时间：
2023-01-04
影响因子：
3.9
通讯作者：
Ahn, Hyochol
中科院分区：
文献类型：
--
作者：
Martorella, Geraldine;Miao, Hongyu;Wang, Duo;Park, Lindsey;Mathis, Kenneth;Park, JuYoung;Sheffler, Julia;Granville, Lisa;Teixeira, Antonio L.;Schulz, Paul E.;Ahn, Hyochol
关键词：
虽然经颅直流电刺激（tDCS）正在成为一种方便的疼痛缓解方式的几种慢性疼痛条件，其可行性，可接受性，并与阿尔茨海默氏病和相关痴呆症（ADRD）患者的疼痛的初步疗效尚未进行研究。这项试点研究的目的是评估5，20分钟的家庭为基础的tDCS会议的可行性，可接受性和初步疗效慢性疼痛的老年人与ADRD。我们将40名参与者随机分配到活动（n = 20）或假手术（n = 20）tDCS组。使用数字评定量表（NRS）评估患者的临床疼痛强度，并使用代理测量（MOBID-2）评估护理人员的临床疼痛强度。我们观察到活性tDCS组患者的疼痛强度显著降低，如两种疼痛测量所反映的（NRS：Cohen d = 0.69，p值= 0.02; MOBID-2：Cohen d = 1.12，p值= 0.001）。此外，我们发现，以家庭为基础的tDCS是可行的和可接受的干预方法，疼痛的ADRD。这些结果表明，需要进行大规模的随机对照研究，使用更大的样本和扩展版本的tDCS来缓解ADRD患者的长期慢性疼痛。
Although transcranial direct current stimulation (tDCS) is emerging as a convenient pain relief modality for several chronic pain conditions, its feasibility, acceptability, and preliminary efficacy on pain in patients with Alzheimer’s disease and related dementias (ADRD) have not been investigated. The purpose of this pilot study was to assess the feasibility, acceptability, and preliminary efficacy of 5, 20-min home-based tDCS sessions on chronic pain in older adults with ADRD. We randomly assigned 40 participants to active (n = 20) or sham (n = 20) tDCS. Clinical pain intensity was assessed using a numeric rating scale (NRS) with patients and a proxy measure (MOBID-2) with caregivers. We observed significant reductions of pain intensity for patients in the active tDCS group as reflected by both pain measures (NRS: Cohen’s d = 0.69, p-value = 0.02); MOBID-2: Cohen’s d = 1.12, p-value = 0.001). Moreover, we found home-based tDCS was feasible and acceptable intervention approach for pain in ADRD. These findings suggest the need for large-scale randomized controlled studies with larger samples and extended versions of tDCS to relieve chronic pain on the long-term for individuals with ADRD.
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影响因子：
3
作者：
Charvet LE;Kasschau M;Datta A;Knotkova H;Stevens MC;Alonzo A;Loo C;Krull KR;Bikson M
通讯作者：
Bikson M
影响因子：
9.9
作者：
Cummings, JL
通讯作者：
Cummings, JL
高清经颅直流刺激对纤维肌痛疼痛的临床有效治疗：II期开放标签剂量优化。
DOI：
10.1016/j.jpain.2015.09.009
发表时间：
2016-01
期刊：
The journal of pain
影响因子：
--
作者：
Castillo-Saavedra L;Gebodh N;Bikson M;Diaz-Cruz C;Brandao R;Coutinho L;Truong D;Datta A;Shani-Hershkovich R;Weiss M;Laufer I;Reches A;Peremen Z;Geva A;Parra LC;Fregni F
通讯作者：
Fregni F
影响因子：
14
作者：
通讯作者：
--
影响因子：
3.6
作者：
Cole, Leonie J.;Gavrilescu, Maria;Egan, Gary F.
通讯作者：
Egan, Gary F.