CHEMICAL SENSITIZATION OF PSEUDOMONAS SPECIES TO IONIZING RADIATION
CHEMICAL SENSITIZATION OF PSEUDOMONAS SPECIES TO IONIZING RADIATION
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DOI：
10.2307/3571155
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发表时间：
1962-01-01
影响因子：
3.4
通讯作者：
BRIDGES, BA
中科院分区：
文献类型：
--
作者：
BRIDGES, BA
研究了N-乙基马来酰亚胺等化合物对假单胞菌的辐射增敏作用。在与N-乙基马来酰亚胺化学相关的化合物中，马来酸酐和间亚苯基双马来酰亚胺敏化，而N-乙基马来酰胺酸、马来酸和琥珀酰亚胺无活性。5元杂环中的双键（与巯基反应的能力相关）可能是该类化合物致敏活性的原因。另外两个巯基试剂，碘乙酸和苯汞乙酸，也敏化假单胞菌属。没有观察到辐射损伤的增强时，敏化剂在照射后1分钟内加入。在其他地方已经提出了一个假设，其中二硫键的断裂和重组被假定为细菌中能量耗散的机制。有人建议在这里，敏化剂可能会阻止这一过程中结合的-SH基团或-S[度]自由基所产生的键断裂。
The sensitization of Pseudomonas sp. to radiation by N-ethylmaleimide and various other compounds was studied. Of compounds chemically related to N-ethylmaleimide which were tested, maleic anhydride and m-phenylene-dimaleimide sensitized, and N-ethylmaleamic acid, maleic acid and succinimide were inactive. The double bond in a 5-membered hetero-cyclic ring (correlated with the ability to react with sulphydryl groups) is probably responsible for the sensitizing activity of this class of compound. Two other sulphydryl reagents, iodoacetic acid and phenylmercuric acetate, also sensitized Pseudomonas sp. No enhancement of radiation damage was observed when sensitizing agents were added within 1 minute after irradiation. A hypothesis has been formulated elsewhere in which the breaking and reforming of disulphide bonds is postulated to be a mechanism of energy dissipation in bacteria. It is suggested here that sensitizing agents might prevent this process by combining with the -SH groups or -S[degree] free radicals arising from bond breakage.