Ambulatory 24-Hour Pharyngeal pH Monitoring in Healthy Korean Volunteers
Ambulatory 24-Hour Pharyngeal pH Monitoring in Healthy Korean Volunteers
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DOI：
10.1007/s10620-008-0684-1
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发表时间：
2009-12-01
影响因子：
3.1
通讯作者：
Lee, Kang Dae
中科院分区：
文献类型：
--
作者：
Moon, Won;Park, Moo In;Lee, Kang Dae
咽部pH监测是咽喉反流（LPR）的标准诊断方法。然而，亚洲人群的正常值仍然未知。我们评估了健康志愿者24小时流动咽部pH监测的结果，以确定韩国人群的正常参考值。30名健康受试者接受了24小时咽部pH值动态监测，玻璃电极位于食管上括约肌上方1 cm和食管下括约肌上方5 cm处，基于上消化道内镜检查后的食管测压。LPR发生在大约一半的健康志愿者中，与年龄、性别和体重指数无显著相关性。咽部酸反流主要发生在直立位。在第95和第90百分位数，排除进餐时间后，咽酸暴露的正常上限（ULN）为0.41%和0.18%。咽酸事件数量的ULN分别为12.8和5.0。相应的食管ULN分别为5.1%和3.8%以及62.7和32.6。本研究的结果有助于建立韩国患者LPR的参考标准。
Pharyngeal pH monitoring is the standard diagnostic approach for laryngopharyngeal reflux (LPR). However, the normal values for Asian populations are still unknown. We evaluated the results of ambulatory 24-h pharyngeal pH monitoring in healthy volunteers to determine the normal reference values in the Korean population. Thirty healthy subjects underwent ambulatory 24-h pharyngeal pH monitoring with glass electrodes positioned 1 cm above the upper esophageal sphincter and 5 cm above the lower esophageal sphincter, based on esophageal manometry after upper gastrointestinal endoscopy. LPR occurred in about one half of the healthy volunteers without any significant association with age, gender and body mass index. Pharyngeal acid reflux occurred mainly in the upright position. At the 95th and 90th percentile, after the exclusion of mealtimes, the upper limits of normal (ULN) for pharyngeal acid exposure were 0.41% and 0.18%. The ULNs for the number of pharyngeal acid events were 12.8 and 5.0. The corresponding ULNs for the esophagus were 5.1% and 3.8% and 62.7 and 32.6. The findings of this study help establish the reference standards for LPR in Korean patients.