Somatic plasticity of neural stem cells: fact or fancy?
Somatic plasticity of neural stem cells: fact or fancy?
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神经干细胞的体细胞可塑性：事实还是幻想？
DOI：
10.1002/jcb.10314
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Recht,Lawrence
中科院分区：
文献类型：
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作者：
Greco,Beatrice;Recht,Lawrence
一些研究已经描述了胚胎和成人神经干细胞分化为非神经细胞的潜力，如肌肉和血液，这些组织来自非神经外胚层。这增加了令人兴奋的可能性，即这些细胞具有比最初想象的更广泛的分化潜力，并为可能的移植利用带来了有趣的前景。然而，最近的一些报告提出了问题，即所观察到的现象是否真的代表了体细胞的可塑性。在这篇综述中，我们对这些研究进行了批判性的分析，目的是提供一些标准，根据这些标准来评估未来解决这一重要问题的研究。©2002 Wiley-Liss公司
Several studies have described the potential for embryonic and adult neural stem cells to differentiate into non‐neural cells such as muscle and blood, tissues that are derived from non‐neuroectodermal germ layers. This raised the exciting possibility that these cells possessed a broader range of differentiation potential than originally thought and raised interesting prospects for possible transplantation utilization. However, a number of recent reports have raised questions about whether the phenomena observed actually represented true somatic plasticity. In this review, we critically analyze these studies with the aim of providing some criteria by which future studies that address this important problem may be evaluated. © 2002 Wiley‐Liss, Inc.