Synthesis of 3-carene-derived nanocellulose/1,3,4-thiadiazole-amide complexes with antifungal activity for plant protection
Synthesis of 3-carene-derived nanocellulose/1,3,4-thiadiazole-amide complexes with antifungal activity for plant protection
复制标题
用于植物保护的具有抗真菌活性的3-蒈烯衍生纳米纤维素/1,3,4-噻二唑酰胺复合物的合成
DOI：
10.1002/ps.6952
复制
发表时间：
2022
影响因子：
4.1
通讯作者：
Yucheng Cui
中科院分区：
文献类型：
--
作者：
Renxuan Zou;Baoyu Li;Wengui Duan;Guishan Lin;Yucheng Cui
纳米农药已被证明是解决农业问题的有力和有前途的工具。本研究旨在通过两种天然生物质资源的综合利用策略，开发生态友好型纳米农药系统（甘蔗渣和松油）因其无与伦比的优势。结果在本研究中，制备了一系列纳米纤维素载体ETOCN-1-ETOCN-4制备了具有不同取代度的（ETOCN，酯化克里思-氧化纤维素纳米纤维），并通过傅里叶变换红外（FTIR）表征，X射线衍射（XRD）和透射电子显微镜（TEM）。设计、合成并表征了21个含偕二甲基环丙烷环的1，3，4-噻二唑酰胺化合物8a-8 u。初步生物测定表明，化合物8i（R = p-Br Ph）对测试的真菌表现出广谱抗真菌活性。此外，将纳米纤维素载体ETOCN-1-ETOCN-4与生物活性化合物8i结合，制备了载药复合物8i/ETOCN-1-8i/ETOCN-4，并对复合物的载药能力、微观结构和缓释性能进行了研究。通过扫描电镜（SEM）观察，小分子药物与载体形成了均匀致密的复合物，在乙醇/水（1：1，v/v）体系中具有良好的载药能力和缓释性能。© 2022化学工业学会。
BACKGROUNDNanopesticides have been proved to be a powerful and promising tool to solve the issues in agriculture. The purpose of the present study was to develop ecofriendly nanopesticide systems by the strategy of comprehensive utilization of two natural biomass resources (bagasse and turpentine oil) because of their incomparable advantages.RESULTSIn this research, a series of nanocellulose carriersETOCN‐1–ETOCN‐4(ETOCN, esterified TEMPO‐oxidized cellulose nanofibers) with different degrees of substitution were prepared and characterized by Fourier‐transform infrared (FTIR), X‐ray diffraction (XRD) and transmission electron microscopy (TEM). Then, 21 1,3,4‐thiadiazole‐amide compounds8a–8ucontaininggem‐dimethylcyclopropane ring were designed, synthesized and characterized. A preliminary bioassay indicated that compound8i(R =p‐Br Ph) exhibited broad‐spectrum antifungal activity against the tested fungi. Furthermore, drug‐loading complexes8i/ETOCN‐1–8i/ETOCN‐4were fabricated by integration of nanocellulose‐based carriersETOCN‐1–ETOCN‐4with bioactive compound8i, and the drug‐loading capacities, microstructures and sustained‐releasing performance of these complexes were also investigated. According to the observation of scanning electron microscopy (SEM) images of complex8i/ETOCN‐2, the small‐molecule drug and the carrier formed a well‐distributed and compact complex, which led to the excellent drug‐loading capacity and sustained‐releasing performance in the ethanol/water (1:1,v/v) system.CONCLUSIONSComplexes8i/ETOCN‐1–8i/ETOCN‐4deserved further study as the promising candidates for the development of nanopesticides. © 2022 Society of Chemical Industry.