Effects of IL-6, adiponectin, CRP and metabolic syndrome on subclinical atherosclerosis.
Effects of IL-6, adiponectin, CRP and metabolic syndrome on subclinical atherosclerosis.
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DOI：
10.1016/j.cca.2007.06.009
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发表时间：
2007-09
期刊：
影响因子：
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通讯作者：
M. Nishida;T. Moriyama;K. Ishii;S. Takashima;K. Yoshizaki;Y. Sugita;K. Yamauchi-Takihara
中科院分区：
文献类型：
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作者：
M. Nishida;T. Moriyama;K. Ishii;S. Takashima;K. Yoshizaki;Y. Sugita;K. Yamauchi-Takihara
炎症与心血管疾病的发病机制有关。由于已经有一些研究阐明性别特异性的炎症和代谢综合征（MetS）对亚临床动脉粥样硬化的影响，我们评估了这些因素在健康subjects. METHODS MetS组件，颈动脉内膜中层厚度（IMT）和脉搏波速度（PWV）的相对贡献进行了评估，在明显健康的714名男性和364名女性（40-59岁）。同时检测血清高敏C反应蛋白（hs-CRP）、白细胞介素6（IL-6）和脂联素水平，发现女性中MetS聚集性组分的增加与IMT和PWV的恶化相关性明显高于男性。男性血清IL-6水平与IMT、PWV呈正相关，脂联素水平与IMT呈负相关，女性则无相关性。受试者无论是“高”IL-6或hs-CRP，或“低”脂联素与增加IMT中存在的MetS，虽然有没有显着的影响MetS在那些低inflammation.CONCLUSIONSWhile IL-6和脂联素是重要的危险因素，在男性的早期动脉改变，MetS的成分，亚临床动脉粥样硬化的妇女，而不是在男性的影响深远。
BACKGROUNDInflammation has been implicated in the pathogenesis of cardiovascular disease. Since there have been few studies elucidating gender-specific effect of inflammation and metabolic syndrome (MetS) on subclinical atherosclerosis, we evaluated the relative contribution of these factors in healthy subjects.METHODSMetS components, carotid intima-media thickness (IMT) and pulse wave velocity (PWV) were evaluated in apparently healthy 714 men and 364 women (40–59 y). Serum levels of high sensitive C-reactive protein (hs-CRP), interleukin-6 (IL-6) and adiponectin were also examined.RESULTSIncrease in number of clustering MetS components was more clearly associated with worsening of IMT and PWV in women than in men. Serum IL-6 level was positively correlated with IMT and PWV, and adiponectin level was negatively correlated with IMT in men but not in women. The subjects either with a “high” IL-6 or hs-CRP, or a “low” adiponectin were associated with increase in IMT in the presence of MetS, though there was no significant effect of MetS in those with low inflammation.CONCLUSIONSWhile IL-6 and adiponectin are the important risk factors for early arterial alterations in men, components of MetS present profound effects on subclinical atherosclerosis in women rather than in men.