SUPPRESSION OF TUMOR-CELL GROWTH AND MITOGEN RESPONSE BY APORPHINE ALKALOIDS, DICENTRINE, GLAUCINE, CORYDINE, AND APOMORPHINE
SUPPRESSION OF TUMOR-CELL GROWTH AND MITOGEN RESPONSE BY APORPHINE ALKALOIDS, DICENTRINE, GLAUCINE, CORYDINE, AND APOMORPHINE
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DOI：
10.1248/bpb1978.13.426
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发表时间：
1990-07-01
期刊：
影响因子：
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通讯作者：
NOZOE, S
中科院分区：
文献类型：
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作者：
KONDO, Y;IMAI, Y;NOZOE, S
阿朴啡生物碱，dicentrine，glaucine，corydine，和阿朴吗啡显示出对几种小鼠肿瘤细胞系，白血病P388和L1210，黑色素瘤B16，膀胱癌MBC 2，和结肠癌Colon 26的抑制活性。这些阿朴啡生物碱还以剂量依赖方式抑制丝裂原诱导的淋巴细胞增殖以及IL-2依赖的CTLL 2细胞系的生长。在这四种生物碱中，阿扑吗啡的抑制作用最强。 阿扑吗啡处理导致腹膜内接种P388的小鼠的存活时间有所延长，尽管其活性不足以满足抗肿瘤活性的标准标准。
The aporphine alkaloids, dicentrine, glaucine, corydine, and apomorphine were shown to have inhibitory activity against several mouse tumor cell lines, leukemia P388 and L1210, melanoma B16, bladder cancer MBC2, and colon cancer Colon 26 in culture. These aporphine alkaloids also inhibited the mitogen-induced lymphocyte proliferation as well as the growth of IL-2 dependent CTLL2 line in a dose-dependent way. Of the four alkaloids apomorphine proved to be most potent in the inhibitory action. Apomorphine treatment resulted in some prolongation of survival time of the mice inoculated i.p. with P388, although its activity was not enough to meet the standard criterion for antitumor activity.