Down-regulation of placental folate transporters in intrauterine growth restriction
Down-regulation of placental folate transporters in intrauterine growth restriction
复制标题
宫内生长受限中胎盘叶酸转运蛋白的下调
DOI：
10.1016/j.jnutbio.2018.06.003
复制
发表时间：
2018-09-01
影响因子：
5.6
通讯作者：
Jansson, Thomas
中科院分区：
文献类型：
--
作者：
Chen, Yi-Yung;Gupta, Madhulika B.;Jansson, Thomas
妊娠期叶酸缺乏与神经管缺陷、胎儿生长受限以及胎儿日后疾病的发生有关。胎儿叶酸的可用性取决于母体叶酸水平和胎盘叶酸转运能力，由两种关键转运蛋白：叶酸受体-a 和还原叶酸载体 (RFC) 介导。我们测试了这样的假设：宫内生长受限（IUGR）与分离的合体滋养层微绒毛质膜（MVM）中叶酸转运蛋白表达和活性降低有关。妊娠并发 IUGR（出生体重）的女性
Folate deficiency in pregnancy is associated with neural tube defects, restricted fetal growth and fetal programming of diseases later in life. Fetal folate availability is dependent on maternal folate levels and placental folate transport capacity, mediated by two key transporters, Folate Receptor-a and Reduced Folate Carrier (RFC). We tested the hypothesis that intrauterine growth restriction (IUGR) is associated with decreased folate transporter expression and activity in isolated syncytiotrophoblast microvillous plasma membranes (MVM). Women with pregnancies complicated by IUGR (birth weight