Use of CD134 as a primary receptor by the feline immunodeficiency virus
Use of CD134 as a primary receptor by the feline immunodeficiency virus
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DOI：
10.1126/science.1092124
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发表时间：
2004-02-20
期刊：
影响因子：
56.9
通讯作者：
Willett, BJ
中科院分区：
文献类型：
--
作者：
Shimojima, M;Miyazawa, T;Willett, BJ
猫免疫缺陷病毒(FIV)在猫体内引起一种类似获得性免疫缺陷综合征(AIDS)的疾病，但与人类免疫缺陷病毒(HIV)不同的是，CD4不是病毒受体。我们发现FIV的主要受体是CD134(OX40)，它是一种T细胞活化抗原和共刺激分子。CD134的表达促进病毒结合，使细胞允许病毒进入、生产性感染和合胞体形成。感染依赖于CXCR4，类似于感染X4毒株的艾滋病毒。因此，尽管猫慢病毒和人类慢病毒在进化上存在差异，但这两种病毒都使用受体，将病毒定位于对获得性免疫反应至关重要的一部分细胞。
Feline immunodeficiency virus (FIV) induces a disease similar to acquired immunodeficiency syndrome (AIDS) in cats, yet in contrast to human immunodeficiency virus (HIV), CD4 is not the viral receptor. We identified a primary receptor for FIV as CD134 (OX40), a T cell activation antigen and costimulatory molecule. CD134 expression promotes viral binding and renders cells permissive for viral entry, productive infection, and syncytium formation. Infection is CXCR4-dependent, analogous to infection with X4 strains of HIV. Thus, despite the evolutionary divergence of the feline and human lentiviruses, both viruses use receptors that target the virus to a subset of cells that are pivotal to the acquired immune response.