Urinary bladder urothelium: Molecular sensors of chemical/thermal/mechanical stimuli
Urinary bladder urothelium: Molecular sensors of chemical/thermal/mechanical stimuli
复制标题
DOI：
10.1016/j.vph.2005.08.027
复制
发表时间：
2006-10-01
影响因子：
4
通讯作者：
Birder, Lori A.
中科院分区：
文献类型：
--
作者：
Birder, Lori A.
膀胱尿路上皮细胞中功能性受体/离子通道的鉴定以及这些感受器分子参与化学介质(一氧化氮，NO；ATP)释放的研究表明，尿路上皮细胞具有特殊的感觉和信号特性。这种机制可以使这些细胞对其化学和物理环境做出反应，并与邻近的尿路上皮细胞以及膀胱壁中的神经进行相互通信。这些和其他发现强调了膀胱尿路上皮功能的重要性，并提示尿路上皮靶点和/或细胞-细胞相互作用的扰动可能导致许多尿路异常。(C)2006 Elsevier Inc.保留所有权利。
The identification of functional receptors/ion channels in bladder urothelial cells and the involvement of these sensor molecules in the release of chemical mediators (nitric oxide, NO; ATP) suggest that urothelial cells exhibit specialized sensory and signaling properties. Such mechanisms could allow these cells to respond to their chemical and physical environments and to engage in reciprocal communication with neighboring urothelial cells as well as nerves in the bladder wall. These and other findings highlight the functional importance of the urinary bladder urothelium and suggest that perturbations in urothelial targets and/or cell-cell interactions may lead to a number of urinary tract abnormalities. (c) 2006 Elsevier Inc. All rights reserved.