Research on establishment of abnormal phlegmatic syndrome with premature ovarian failure rat model and effects of abnormal Balgham Munziq treatment
Research on establishment of abnormal phlegmatic syndrome with premature ovarian failure rat model and effects of abnormal Balgham Munziq treatment
复制标题
异常痰证卵巢早衰大鼠模型的建立及异常Balgham Munziq治疗效果研究
DOI：
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发表时间：
2019
影响因子：
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通讯作者：
Adilijiang Yiming
中科院分区：
文献类型：
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作者：
Xiamixinuer Yilike;Abulizi Keremu;Aziguli Yaoliwasi;Mayire Tuerhong;Nafeisha Kadeer;Heyi;Adilijiang Yiming
本研究旨在建立慢性应激性卵巢早衰（POF）动物模型，探讨其生物学基础，并探讨中药蒙自克对其治疗作用。将性成熟的雌性SD大鼠在寒冷潮湿的环境中用菠菜和香菜喂养约20周，直至建立慢性应激（CS）模型。根据周生物学特征和激素水平（LH、FSF、E2）检测将CS大鼠分为POF应激模型组和应激模型组。为探讨蒙自奇的治疗作用，将POF疾病应激模型组分为高、中、低药物干预组。结果表明，慢性应激（特殊食物、寒冷、潮湿）可导致POF发病;中药蒙齐克不仅能改善生殖激素水平紊乱，还能改善下丘脑-垂体-卵巢轴功能，其作用机制可能是改变血清中E2、LH和FSH激素水平，降低卵巢早衰相关蛋白PFN-1的表达。
The purposes of this study were to establish and to explore the biological basis of the chronic stress induced premature ovarian failure (POF) model, also to explore the therapeutic effects of the traditional Chinese medicine Munziq. Sexually matured female SD rats were fed with spinach and cilantro in cold and wet conditions for about 20 weeks, until a chronic stress (CS) model was established. CS rats were divided into POF stress model group and stress model group according to weekly biological characteristics and hormone level detection (LH, FSF and E2). To investigate the therapeutic effect of Munziqi, the POF disease stress model group was divided into the high, medium and low drug intervention groups. The results showed that chronic stresses (special food, cold, damp) can lead to POF disease; Traditional Chinese medicine Munziq not only improve the reproductive hormone level disorder, but also improve the function of the hypothalamus-pituitary-ovarian axis, its mechanism may be a change E2, LH and FSH hormone levels in serum and lower the expression of ovarian premature aging related protein PFN-1....