Estimates of influenza and respiratory syncytial virus incidences with fraction modeling approach in Baguio City, the Philippines, 2012-2014.
Estimates of influenza and respiratory syncytial virus incidences with fraction modeling approach in Baguio City, the Philippines, 2012-2014.
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DOI：
10.1111/irv.12453
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发表时间：
2017-07
影响因子：
4.4
通讯作者：
Tallo VL
中科院分区：
文献类型：
--
作者：
Kamigaki T;Aldey PP;Mercado ES;Tan AG;Javier JB;Lupisan SP;Oshitani H;Tallo VL
估计流感和呼吸道合胞病毒（RSV）感染的发生率对疾病控制具有重要意义。先前对该市的估计显示，门诊病人和住院病人都有相当大的流感负担，但没有考虑到不寻求医疗照顾或呼吸道合胞病毒的个人。共收集了17 674例流感样疾病（ILI）和13 242例严重急性呼吸道疾病（SARI）病例，分别从6267例和2962例ILI和SARI病例中采集了样本。采用RT - PCR检测样本中的流感病毒和RSV病毒。2014年2月至2014年4月进行了一项寻求健康行为调查，以估计在雨季和旱季之间不寻求医疗照顾的感染者比例。流感和RSV在门诊患者中的平均发病率分别为1.6 / 1000和1.4 / 1000，在6 ~ 23个月年龄组中这两种病毒的发病率最高。流感和呼吸道合胞病毒住院的平均发病率分别为每1000人中1.7人和1.9人。此外，我们估计未就医人群中流感和呼吸道合胞病毒的发病率分别是就医人群的3倍和1.6倍。呼吸道合胞病毒和流感造成重大疾病负担，特别是在住院病例中。实施以社区为基础的方法或加强监测系统与社区调查相结合，将有助于更好地了解菲律宾RSV和流感的疾病负担。
Estimation of the incidences of influenza and respiratory syncytial virus (RSV) infection is important for disease control. Previous estimate in the city showed a substantial burden of influenza in both outpatients and inpatients while it did not account for individuals who do not seek medical attention nor RSV. A total of 17 674 influenza‐like illness (ILI) and 13 242 severe acute respiratory illness (SARI) cases were recruited, and samples were collected from 6267 and 2962 of ILI and SARI cases, respectively. RT‐PCR assays were performed to detect influenza and RSV in the samples. A health‐seeking behavior survey was conducted from February 2014 to April 2014 to estimate the fraction of infected individuals who did not seek medical attention between rainy and dry season. Average influenza and RSV incidence rates in outpatients were 1.6 and 1.4 per 1000 individuals, respectively, and the highest incidence rate for both viruses was found in the of 6‐23 month age group. Average influenza and RSV hospitalization incidence rates were 1.7 and 1.9 per 1000 individuals, respectively. Further, we estimated that the incidence rates of influenza and RSV in individuals who did not seek medical attention were threefold and 1.6‐fold those in the medically attended population. Respiratory syncytial virus and influenza pose a substantial disease burden, particularly in hospitalized cases. The implementation of either a community‐based approach or an enhanced surveillance system in combination with a community survey will allow a better understanding of the disease burdens of RSV and influenza in the Philippines.