Volitional control of single-electrode high gamma local field potentials by people with paralysis.
Volitional control of single-electrode high gamma local field potentials by people with paralysis.
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DOI：
10.1152/jn.00131.2018
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发表时间：
2019-04
影响因子：
2.5
通讯作者：
T. Milekovic;D. Bacher;Anish A. Sarma;J. Simeral;J. Saab;C. Pandarinath;B. Yvert;Brittany L Sorice;C. Blabe;Erin M. Oakley;Kathryn R Tringale;E. Eskandar;S. Cash;K. Shenoy;J. Henderson;L. Hochberg;J. Donoghue
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作者：
T. Milekovic;D. Bacher;Anish A. Sarma;J. Simeral;J. Saab;C. Pandarinath;B. Yvert;Brittany L Sorice;C. Blabe;Erin M. Oakley;Kathryn R Tringale;E. Eskandar;S. Cash;K. Shenoy;J. Henderson;L. Hochberg;J. Donoghue
大脑皮质内脑机接口(BCI)可以使个体通过从运动皮质内记录的动作电位和局部场电位(LFP)直接解码用户的运动意图来控制效应器，例如计算机光标。然而，用这种“仿生的”BCI实现的效应器控制的准确性和复杂性将取决于用于引发控制的预定动作对神经活动的调节程度。具体地，不记录可区分的动作电位并且仅记录LFP调制的通道对于BCI控制的使用可能是有限的。相比之下，生物反馈方法可能会超越这些限制，让参与者产生新的控制信号，并学习改善用于效应器控制的信号的意志控制的策略。在这里，我们展示了，通过使用生物反馈范式，三个四肢瘫痪患者通过植入中央前回的单个微电极实现了对伽马LFP(40-400赫兹)的意志控制。在长达3天的两个连续疗程中，控制率得到了改善。除一次外，所有用于实现控制的通道都缺乏可区分的动作电位。我们的结果表明，基于生物反馈LFP的BCI可能有助于神经调制，从而获得可靠和有用的效应器控制。新的&值得注意的是，我们的研究表明，四肢瘫痪患者可以自愿控制从运动皮质记录的单个高伽马局部场电位(LFP)通道，并且这种控制可以使用生物反馈来改善。运动皮质LFP信号被认为既是信息性的，又是稳定的皮质内信号，因此对未来的脑-计算机接口具有重要意义。
Intracortical brain-computer interfaces (BCIs) can enable individuals to control effectors, such as a computer cursor, by directly decoding the user's movement intentions from action potentials and local field potentials (LFPs) recorded within the motor cortex. However, the accuracy and complexity of effector control achieved with such "biomimetic" BCIs will depend on the degree to which the intended movements used to elicit control modulate the neural activity. In particular, channels that do not record distinguishable action potentials and only record LFP modulations may be of limited use for BCI control. In contrast, a biofeedback approach may surpass these limitations by letting the participants generate new control signals and learn strategies that improve the volitional control of signals used for effector control. Here, we show that, by using a biofeedback paradigm, three individuals with tetraplegia achieved volitional control of gamma LFPs (40-400 Hz) recorded by a single microelectrode implanted in the precentral gyrus. Control was improved over a pair of consecutive sessions up to 3 days apart. In all but one session, the channel used to achieve control lacked distinguishable action potentials. Our results indicate that biofeedback LFP-based BCIs may potentially contribute to the neural modulation necessary to obtain reliable and useful control of effectors. NEW & NOTEWORTHY Our study demonstrates that people with tetraplegia can volitionally control individual high-gamma local-field potential (LFP) channels recorded from the motor cortex, and that this control can be improved using biofeedback. Motor cortical LFP signals are thought to be both informative and stable intracortical signals and, thus, of importance for future brain-computer interfaces.