A Novel Nonhuman Primate Model of Nonatopic Asthma.
A Novel Nonhuman Primate Model of Nonatopic Asthma.
复制标题
一种新的非人类灵长类非过敏性哮喘模型。
DOI：
10.1007/978-1-0716-2364-0_6
复制
发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Haczku,Angela
中科院分区：
文献类型：
--
作者：
Royer,Christopher;Miller,LisaA;Haczku,Angela
非人灵长类动物模型在理解进行性呼吸道疾病的发病机制方面具有重要作用。非人灵长类动物的免疫和生理参数密切反映了人类系统的复杂性，并为研究环境暴露下粘膜免疫变化提供了特殊的翻译影响。这种潜力保证了新模型的发展，这些模型将阐明呼吸系统疾病与可吸入环境的相互作用，以及新疗法的潜力，以减轻这些相互作用的不良结果。非人类灵长类动物的哮喘模型可以是自发的，诱导的，或通过各种暴露实验操纵。在这里，我们描述了一个模型的气道高反应性加剧引起暴露于空气污染物，臭氧，在一群年轻的成年哮喘恒河猴。
Nonhuman primate models have an essential role in understanding progressive respiratory disease pathogenesis. Immune and physiologic parameters in the nonhuman primate closely reflect the complexity of human systems and provide an exceptional translational impact for the investigation of the mucosal immune changes in response to environmental exposures. This potential warrants the development of novel models that will clarify the interaction of respiratory disease and the inhalable environment and the potential of novel therapies to alleviate the untoward results of these interactions. Nonhuman primate models of asthma can be spontaneous, induced, or experimentally manipulated by various exposures. Here we describe a model of exacerbation of airway hyperreactivity induced by exposure to an air pollutant, ozone, in a cohort of young adult asthmatic rhesus macaques.