SYNCHRONOUS BURSTS OF ACTION-POTENTIALS IN GANGLION-CELLS OF THE DEVELOPING MAMMALIAN RETINA
SYNCHRONOUS BURSTS OF ACTION-POTENTIALS IN GANGLION-CELLS OF THE DEVELOPING MAMMALIAN RETINA
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DOI：
10.1126/science.2035024
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发表时间：
1991-05-17
期刊：
影响因子：
56.9
通讯作者：
SHATZ, CJ
中科院分区：
文献类型：
--
作者：
MEISTER, M;WONG, ROL;SHATZ, CJ
哺乳动物视觉系统中有序连接的发展依赖于视神经纤维中的动作电位，甚至在视网膜接收视觉输入之前。特别是，已经提出，在同一只眼睛中的视网膜神经节细胞的相关发射指导其突触末端分离到外侧膝状体核内的眼睛特异性层中。这种相关性的电活动中发现的同时记录的细胞外动作电位高达100神经节细胞在离体视网膜的新生雪貂和胎猫。这些神经元发射的尖峰在近同步的爆发持续几秒钟，并分开1至2分钟的沉默。单个爆发由几百微米宽的兴奋波组成，以每秒100微米的速度扫过视网膜。这些一致的放电模式具有适当的空间和时间特性，以指导视网膜和外侧膝状体核之间的连接的细化。
The development of orderly connections in the mammalian visual system depends on action potentials in the optic nerve fibers, even before the retina receives visual input. In particular, it has been suggested that correlated firing of retinal ganglion cells in the same eye directs the segregation of their synaptic terminals into eye-specific layers within the lateral geniculate nucleus. Such correlations in electrical activity were found by simultaneous recording of the extracellular action potentials of up to 100 ganglion cells in the isolated retina of the newborn ferret and the fetal cat. These neurons fired spikes in nearly synchronous bursts lasting a few seconds and separated by 1 to 2 minutes of silence. Individual bursts consisted of a wave of excitation, several hundred micrometers wide, sweeping across the retina at about 100 micrometers per second. These concerted firing patterns have the appropriate spatial and temporal properties to guide the refinement of connections between the retina and the lateral geniculate nucleus.