Prediction of Primary Somatosensory Neuron Activity During Active Tactile Exploration
Prediction of Primary Somatosensory Neuron Activity During Active Tactile Exploration
复制标题
主动触觉探索过程中初级体感神经元活动的预测
DOI：
10.1101/024364
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Campagner D
中科院分区：
文献类型：
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作者：
Campagner D
初级感觉神经元形成世界和大脑之间的界面。它们的功能在被动刺激期间是很好理解的，但是在自然行为条件下，感觉器官处于主动运动控制下。在试图预测初级神经元放电的感觉运动整合的自然条件下，我们记录从初级mechanosensory神经元清醒，头部固定的小鼠，因为他们探索了一个极与他们的胡须，并同时测量胡须运动和力与高速摄像。使用广义线性模型，我们发现胡须角度对初级神经元反应的预测很差，但作用在胡须上的旋转力可以很好地预测：无论是在触摸还是在自由空气胡须运动期间。这些结果是在明显的对比，以前的研究被动刺激，但可以调和主动和被动条件之间的运动学-力的关系的差异。因此，简单的统计模型可以预测丰富的神经活动所引发的自然，探索性的行为，涉及积极运动的感觉器官。http://dx.doi.org/10.7554/eLife.10696.001
Primary sensory neurons form the interface between world and brain. Their function is well-understood during passive stimulation but, under natural behaving conditions, sense organs are under active, motor control. In an attempt to predict primary neuron firing under natural conditions of sensorimotor integration, we recorded from primary mechanosensory neurons of awake, head-fixed mice as they explored a pole with their whiskers, and simultaneously measured both whisker motion and forces with high-speed videography. Using Generalised Linear Models, we found that primary neuron responses were poorly predicted by whisker angle, but well-predicted by rotational forces acting on the whisker: both during touch and free-air whisker motion. These results are in apparent contrast to previous studies of passive stimulation, but could be reconciled by differences in the kinematics-force relationship between active and passive conditions. Thus, simple statistical models can predict rich neural activity elicited by natural, exploratory behaviour involving active movement of sense organs.DOI:http://dx.doi.org/10.7554/eLife.10696.001