Copper(II) triflate as a double catalyst for the one-pot click synthesis of 1,4-disubstituted 1,2,3-triazoles from benzylic acetates
Copper(II) triflate as a double catalyst for the one-pot click synthesis of 1,4-disubstituted 1,2,3-triazoles from benzylic acetates
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DOI：
10.1055/s-2007-986638
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发表时间：
2007-09-17
期刊：
影响因子：
2
通讯作者：
Kikuchi, Satoshi
中科院分区：
文献类型：
--
作者：
Fukuzawa, Shin-ichi;Shimizu, Eiji;Kikuchi, Satoshi
三氟化铜(II)在一锅中催化TSMN3取代乙酸苄酯和随后的1，3-偶极加成反应。该方法无需使用单一催化剂分离有机叠氮，即可从易得的乙酸酯出发，以良好的产率制备1，4-二取代的1，2，3-三氮唑。
Copper(II) triflate doubly catalyzed the substitution of benzylic acetates by TMSN3 and the subsequent 1,3-dipolar addition with an alkyne in one pot. This procedure afforded the preparation of 1,4-disubstituted 1,2,3-triazoles in good yields starting from the easily accessible acetates without isolating an organic azide using a single catalyst.