17β-estradiol:: Effect on CA1 hippocampal synaptic plasticity
17β-estradiol:: Effect on CA1 hippocampal synaptic plasticity
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DOI：
10.1006/nlme.2001.4018
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发表时间：
2001-11-01
影响因子：
2.7
通讯作者：
Foy, MR
中科院分区：
文献类型：
--
作者：
Foy, MR
An understanding of synaptic plasticity in the mammalian brain has been one of R. F. Thompson's major pursuits throughout his illustrious career. A current series of experiments of significant interest to R. F. Thompson is an examination of the interactions between sex hormones, synaptic plasticity, aging, and stress. This research is contained within a broader project whose aim is to investigate animal models that evaluate estrogen interactions with Alzheimer's disease. This paper reviews the recent results that have led to a better understanding of how the sex hormone estrogen influences synaptic plasticity in an important structure within the mammalian brain responsible for learning and memory: the hippocampus. In this review, a number of experiments have been highlighted that investigate the molecular mechanisms that underlie estrogen's effect on two specific forms of synaptic plasticity commonly studied in neurophysiology and the behavioral neurosciences: long-term potentiation and long-term depression. (C) 2001 Academic Press
