POSITIVE DARWINIAN EVOLUTION IN HUMAN INFLUENZA-A VIRUSES
POSITIVE DARWINIAN EVOLUTION IN HUMAN INFLUENZA-A VIRUSES
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DOI：
10.1073/pnas.88.10.4270
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发表时间：
1991-05-01
影响因子：
11.1
通讯作者：
PALESE, P
中科院分区：
文献类型：
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作者：
FITCH, WM;LEITER, JME;PALESE, P
我们先前提出，A型人类流感病毒基因通过免疫监视进行积极的达尔文选择。 这就需要在存活的谱系中比在灭绝的谱系中更有利的氨基酸替换固定在抗原位点中。 我们现在表明，病毒血凝素固定比例更多的氨基酸置换抗原位点在树干的进化树（幸存者）比在分支（nonsurvivors），表明A型人流感病毒正在经历积极的达尔文进化。 血凝素基因的进化速度是非结构基因的3倍，而样本中的非幸存者的平均年龄只有1.6岁，因此灭绝不仅常见，而且迅速。
We earlier suggested that type A human influenza virus genes undergo positive Darwinian selection through immune surveillance. This requires more favorable amino acid replacements fixed in antigenic sites among the surviving lineages than among the extinct lineages. We now show that viral hemagglutinins fix proportionately more amino acid replacements in antigenic sites in the trunk of the evolutionary tree (survivors) than in the branches (nonsurvivors), demonstrating that type A human influenza virus is undergoing positive Darwinian evolution. The hemagglutinin gene is evolving 3 times faster than the nonstructural gene and the average age of the sampled nonsurvivors is only 1.6 years, so that extinction is not only common but rapid.