Functional consequences of lumbar spinal cord contusion injuries in the adult rat
Functional consequences of lumbar spinal cord contusion injuries in the adult rat
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DOI：
10.1089/neu.2005.22.529
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发表时间：
2005-05-01
影响因子：
4.2
通讯作者：
Burke, DA
中科院分区：
文献类型：
--
作者：
Magnuson, DSK;Lovett, R;Burke, DA
我们对运动基础的理解，以及因此对脊髓损伤后缺陷原因的理解，仍然不完整。虽然挫伤或撕裂伤或胸脊髓腹侧和腹外侧白质脱髓鞘可引起严重的运动缺陷，但中胸灰质的丧失（椎管内红藻氨酸注射）对运动没有影响。相反，腰椎头端灰质的丧失会导致严重的运动缺陷。本研究检查了成年大鼠腰椎增大的头端部挫伤后的组织学和运动结果。成年 Sprague-Dawley 大鼠遭受以 T13/L1、L2 或 L3/4 脊髓节段为中心的挫伤。尽管总灰质体积损失明显较小（1.7 与 2.7 mm(3)），但以 T13/L1 和 L2 脊髓节段为中心的中度严重损伤比以 L3/4 节段为中心的损伤引起更严重的运动缺陷。 T13/L1、L2 和 L3/4 处的中重度损伤分别显示 21%、31% 和 39% 的白质保留，6 周 BBB 评分分别为 10、10 和 15.7。这些数据表明，以腰椎增大的头侧段为中心的中度严重挫伤会导致比组织学结果（白质幸免）预测的更严重的运动缺陷，这表明灰质损失可能在一些腰椎挫伤后的功能缺陷中发挥作用。
Our understanding of the substrates of locomotion, and hence our understanding of the causes of deficits following spinal cord injury, is still incomplete. While severe locomotor deficits can be induced by either contusion or laceration injuries or demyelination of thoracic spinal cord ventral and ventrolateral white matter, loss of mid-thoracic gray matter (intraspinal kainic acid injection) has no impact on locomotion. In contrast, loss of gray matter from the rostral lumbar segments induces severe locomotor deficits. This study examines the histological and locomotor outcomes following contusion injuries involving the rostral segments of the lumbar enlargement in the adult rat. Adult Sprague-Dawley rats received contusion injuries centered on the T13/L1, L2, or L3/4 spinal cord segments. Moderately severe injuries centered on the T13/L1 and L2 spinal cord segments induced more severe locomotor deficits than those centered on the L3/4 segments, despite a significantly smaller total gray matter volume loss (1.7 vs. 2.7 mm(3)). Moderately-severe injuries at T13/L1, L2, and L3/4 showed 21%, 31%, and 39% white matter sparing, respectively, with 6-week BBB scores of 10, 10, and 15.7, respectively. These data suggest that moderately-severe contusion injuries centered on the rostral segments of the lumbar enlargement induce more severe locomotor deficits than would be predicted by the histological outcome (spared white matter), suggesting that gray matter loss may play a role in functional deficits following some lumbar contusion injuries.