INBREEDING OF WISTAR-KYOTO RAT STRAIN WITH HYPERACTIVITY BUT WITHOUT HYPERTENSION
INBREEDING OF WISTAR-KYOTO RAT STRAIN WITH HYPERACTIVITY BUT WITHOUT HYPERTENSION
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DOI：
10.1016/s0163-1047(86)80001-2
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发表时间：
1986-01-01
期刊：
影响因子：
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通讯作者：
VANHOUTEN, J
中科院分区：
文献类型：
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作者：
HENDLEY, ED;WESSEL, DJ;VANHOUTEN, J
采用Wistar-Kyoto大鼠品系作为祖先的遗传近交程序，将自发性高血压大鼠（SHR）的高活动性状与WKY遗传对照品系的正常血压性状联合收割机结合。来自SHR. times. WKY杂交产生了一个基因突变的F_2群体，从该群体中通过7个连续的自交群体进行了选择的兄弟姐妹交配。该计划产生了一个新的品系的多动大鼠血压正常的平均收缩压水平，我们已经指定的新品系为Wistar-Kyoto多动（WK/HA）大鼠。SHR大鼠的另一个行为特征是在非强化的新环境中适应性差，但这并不是WK/HA大鼠新品系的特征，这表明这两个特征的潜在遗传基础是独立的，而这两个特征显然是由于该品系的密集近亲繁殖而偶然固定在SHR基因型中的。新的WK/HA品系，连同WKY对照品系，被认为是更适合于受试者在研究多动的大鼠比原来的SHR品系，其伴随的高血压和不良的习惯化特征。
A genetic inbreeding program using Wistar-Kyoto rat strains as progenitors was used to combine the hyperactivity trait of the spontaneously hypertensive rat (SHR) with the normotensive trait of the WKY genetic control strain. From an SHR .times. WKY cross we produced a gene-assorting F2 population from which selected brother-sister matings were carried out through seven successive inbred populations. This program produced a new strain of hyperactive rats with normotensive mean systolic blood pressure levels, and we have designated the new strain as the Wistar-Kyoto hyperactive (WK/HA) rat. Another behavior characteristic of the SHR rat, poor habituation in a nonreinforcing novel environment, did not appear as a characteristic trait of the new strain of WK/HA rats, suggesting a separate underlying genetic basis for the two traits that been apparently fortuitously fixed in the SHR genotype as a result of intensive inbreeding of that strain. The new WK/HA strain, together with the WKY control strain, is considered as more suitable for subjects in studying hyperactivity in rats than the original SHR strain with its concomitant hypertension and poor habituation traits.