HYDROGEN-PEROXIDE PRODUCTION BY LIVER-MITOCHONDRIA IN DIFFERENT SPECIES
HYDROGEN-PEROXIDE PRODUCTION BY LIVER-MITOCHONDRIA IN DIFFERENT SPECIES
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DOI：
10.1016/0047-6374(90)90039-i
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发表时间：
1990-04-30
影响因子：
5.3
通讯作者：
BRUNK, UT
中科院分区：
文献类型：
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作者：
SOHAL, RS;SVENSSON, I;BRUNK, UT
本研究的目的是进一步探讨氧自由基与动物衰老过程的关系。测定了小鼠、大鼠、豚鼠、兔、猪、牛肝脏线粒体中超氧阴离子自由基突变产物H2O2的释放速率，以及果蝇、家蝇、家蝇飞行肌线粒体中H2O2的释放速率。H2O2生成速率与最大寿命潜能（MLSP）呈负相关。在哺乳动物中发现了42倍的H2O2分泌率差异，在昆虫和哺乳动物之间发现了高达300倍的差异。本研究结果表明，在相同条件下，低MLSP动物线粒体释放的H2O2量相对较大。
The objective of this study was to further examine the relationship between oxygen free radicals and the aging process in animals. The rate of H2O2, a product of superoxide anion radical dismutation, released by liver mitochondria, was measured in the mouse, rat, guinea pig, rabbit, pig and cow as well as in flight muscle mitochondria of Drosophila melanogaster of the housefly, Musca domestica. The rate of H2O2 generation was inversely related to the maximum life span potential (MLSP) of the species. A 42-fold difference in the rate of H2O2 secretion was found among mammals and an up to 300-fold difference was noted between the insects and the mammals. Results of this study indicate that under identical conditions mitochondria from animals with low MLSP release relatively greater amounts of H2O2.