Increased mutation frequencies in Escherichia coli isolates harboring extended-spectrum β-lactamases
Increased mutation frequencies in Escherichia coli isolates harboring extended-spectrum β-lactamases
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DOI：
10.1128/aac.49.11.4754-4756.2005
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发表时间：
2005-11-01
影响因子：
4.9
通讯作者：
Baquero, F
中科院分区：
文献类型：
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作者：
Baquero, MR;Galán, JC;Baquero, F
在89株来自不同患者的产超广谱β-内酰胺酶（ESBL）分离株（77个脉冲场凝胶电泳克隆，12个ESBL型）中，高变（突变频率[f]，>= 4 × 10（-8））大肠埃希菌菌株的检出率（43%）高于非ESBL大肠埃希菌。大肠埃希菌（26%）（P = 0.03）。在泌尿道分离株中，超广谱β-内酰胺酶（ESBL）的高突变频率为40%，而非ESBL分离株的高突变频率为26%（P = 0.03）。
Hypermutable (mutation frequency [f], >= 4 x 10(-8)) Escherichia coli strains were more frequently found (43%) in a collection of 89 extended-spectrum P-lactamase (ESBL) -producing isolates from different patients (77 pulsed-field gel electrophoresis clones, 12 ESBL types) than in non-ESBL E. coli (26%) strains (P = 0.03). Among urinary tract isolates, the frequency of hypermutation was 40% in ESBL versus 26% in non-ESBL isolates (P = 0.03).