Obesity and rhinitis in a nationwide study of children and adults in the United States.
Obesity and rhinitis in a nationwide study of children and adults in the United States.
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DOI：
10.1016/j.jaci.2015.12.1307
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发表时间：
2016-05
期刊：
影响因子：
--
通讯作者：
Celedón JC
中科院分区：
文献类型：
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作者：
Han YY;Forno E;Gogna M;Celedón JC
肥胖与儿童和成人患哮喘的风险和哮喘严重程度有关。然而，评估肥胖和鼻炎之间关系的研究得出了相互矛盾的结果。我们使用2005 - 2006年国家健康和营养检查调查中8,165名参与者的数据进行了肥胖指标和鼻炎的横断面研究。过敏性鼻炎定义为医生诊断的花粉热或过敏，在过去12个月内出现症状，至少有一种过敏原特异性IgE阳性。非过敏性鼻炎定义为医生诊断和症状，但没有阳性过敏原特异性IgE。多元回归分析被用来评估儿童和成人肥胖与鼻炎之间的关系。在成人中，超重或肥胖与非过敏性鼻炎的几率增加有关（调整后的比值比[aOR]= 1.43，95%置信区间[CI]= 1.06 - 1.93，P = 0.02）。同样，中心性肥胖与成人非变应性鼻炎的几率增加相关（aOR = 1.61，95% CI = 1.20 - 2.16，P <0.01）。在按性别分层的分析中，观察到的相关性减弱，在女性成年人中变得无统计学意义，但在男性成年人中仍然显着。超重、肥胖或向心性肥胖与成人变应性鼻炎无关。在儿童中，中心性肥胖与变应性鼻炎的发生率降低相关（aOR = 0.35，95% CI = 0.19-0.64，P <0.01）。按性别分层后，这种关联在女性和男性儿童中相似。在成年人中，肥胖与非过敏性鼻炎的几率增加有关，特别是在男性中。在儿童中，无论性别如何，中心性肥胖与变应性鼻炎的几率降低有关。
Obesity has been associated with higher risk of asthma and asthma severity, both in children and adults. However, studies evaluating the relation between obesity and rhinitis have yielded conflicting results. We performed a cross-sectional study of obesity indicators and rhinitis using data from 8,165 participants in the 2005–2006 National Health and Nutrition Examination Survey. Allergic rhinitis was defined as physician-diagnosed hay fever or allergy, presence of symptoms in the past 12 months, and at least one positive allergen-specific IgE. Non-allergic rhinitis was defined as physician diagnosis and symptoms but no positive allergen-specific IgE. Multivariate regression was used to assess the relationship between obesity and rhinitis in children and adults. In adults, being overweight or obese was associated with increased odds of non-allergic rhinitis (adjusted odds ratio [aOR]=1.43, 95% confidence interval [CI]=1.06–1.93, P=0.02). Similarly, central obesity was associated with increased odds of non-allergic rhinitis in adults (aOR=1.61, 95% CI=1.20–2.16, P<0.01). In an analysis stratified by gender, the observed associations were attenuated and became non-statistically significant in female adults, but remained significant in male adults. Overweight, obesity or central obesity were not associated with allergic rhinitis in adults. In children, central obesity was associated with reduced odds of allergic rhinitis (aOR=0.35, 95% CI=0.19–0.64, P<0.01). After stratification by gender, this association was similar in female and male children. In adults, obesity is associated with increased odds of non-allergic rhinitis, particularly in males. In children, central obesity is associated with reduced odds of allergic rhinitis, regardless of gender.